MDMA is a potentially illegal substance, and we do not encourage or condone the use of this substance where it is against the law. However, we accept that illegal drug use occurs, and believe that offering responsible harm reduction information is imperative to keeping people safe. For that reason, this guide is designed to ensure the safety of those who decide to use the substance MDMA (ECSTASY)
MDMA is a synthetic drug that alters mood and perception, often producing feelings of euphoria, empathy, and emotional well-being. Short for 3,4-methylenedioxy-methamphetamine, MDMA is chemically similar to both stimulants and psychedelics. Under its influence, colors and sounds (especially music) are experienced more intensely, which has made it a popular recreational drug, particularly at raves and music festivals. Though it has a reputation as a club drug, MDMA’s ability to help people gain access to their emotions made it a popular drug to treat depression in the late 1970s, as well as in couples therapy to foster closeness. The psychologist and psychotherapist who first brought MDMA to the world of psychotherapy, Leo Zeff, reportedly called the drug “penicillin for the soul.” But after it became a popular recreational drug, the DEA added MDMA to the list of Schedule 1 drugs in 1985. Buy MDMA Italy
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In the early 2000s, however, the Multidisciplinary Association for Psychedelic Studies (MAPS) launched the first clinical study into MDMA’s therapeutic potential, specifically for PTSD. In one study, 68% of the 107 participants involved no longer had PTSD one year after treatment. Now, pure crystal MDMA (the only form of the drug that may be legally administered by a medical professional) is in Phase III clinical trials for use as a therapeutic aid in the treatment of PTSD and has been granted “Breakthrough Therapy” status by the FDA. MDMA is on track for full FDA approval and could be prescribed by doctors as early as 2022. Buy MDMA Germany
MDMA also has the potential to alleviate social anxiety and save struggling relationships.
MDMA can be deadly at high doses and when combined with other drugs, especially PMA/PMMA, MDMA (ECSTASY)
Many factors contribute to the MDMA (ECSTASY) experience, including dose, mindset, and setting. While there’s no way to predict exactly what will happen, following the Six S’s can help ensure you’ll have a positive experience with minimal negative effects. Buy MDMA France
WHAT TO EXPECT FROM MDMA
For most clinical trials, researchers administer doses between 80 and 150mg of MDMA (ECSTASY). At this dose level, the onset of effects occurs approximately 20 to 60 minutes after taking the drug, and the characteristic effects (euphoria, increased empathy, and energy, enhanced sensations) typically last for three to five hours. Buy MDMA UK
The high is usually characterized by a relaxed, euphoric state, including emotional openness, reduction of negative thoughts, and a decrease in inhibitions. XTC (ECSTASY) can make users feel like all is well in the world, and connecting with others becomes easy. Bodily sensations and touch become enhanced, and sounds and colors can appear more intense. Buy MDMA Switzerland
These effects themselves could be important to the drug’s healing potential by offering users greater access to their inner selves. But researchers also believe that the openness MOLLY (ECSTASY) fosters could speed up the bond between patient and therapist, creating a setting conducive to healing. Buy MDMA Netherlands
PURE MDMA
Your experience will also be affected by the quality of the MDMA you ingest. MDMA purity is notoriously variable, especially in tablet form. In the US, for instance, the average MDMA concentration in ecstasy tablets is reported to be 30.13%.[1] But this includes samples as low as 0% and as high as 100%. Also, while the sample size varies (from 1 to 1,000 pills), individual state averages can be double or half the national average. Buy MDMA Greece
Still, this is an improvement: In 2008, police seizures of the chemical precursor safrole meant that, for years, street MDMA concentration in pills was often zero.[2] Since then, the percentage of dud pills (tablets containing no MDMA) has been falling. Meanwhile, the percentage of ecstasy pills containing MDMA (ECSTASY) alone, without any adulterants, has been climbing. In 2009, 60.1% of ecstasy tablets worldwide contained no MDMA, whereas just 8.7% contained MDMA alone. By 2018, the situation was reversed: 8.8% of ecstasy tablets contained no MDMA, while 54.8% contained MDMA alone. Buy MDMA Poland
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Part of this has to do with new manufacturing methods. Underground chemists now synthesize the drug with a less heavily restricted precursor. But it also has to do with the darknet, where vendor ratings and competition drive the quality up. Buy MDMA Russia
Far from the time when there was too little MDMA in pills, nowadays there’s often too much. Super-strength ecstasy tablets have made headlines in recent years for killing unsuspecting users. Where the MDMA content in ecstasy pills is traditionally between 80 and 120mg, some have been found to contain upwards of 300mg.[5] A high-end dose like this can be dangerous enough in itself, let alone when you’re not expecting it. Buy MDMA pills
Reagent test kits from Bunk Police in addition to the services provided by EcstasyData.org and Pill Reports are excellent resources for gauging pill safety. Short of testing the drug before consuming it, the safest way to use ecstasy pills is to start with half a tablet and gauge how you feel after an hour. Buy MDMA Australia
PHARMACOLOGY
MDMA affects the brain by increasing the activity levels of three neurotransmitters: dopamine, norepinephrine (noradrenaline), and serotonin. Buy Molly Australia
Increases in dopamine are what create MDMA’s euphoric effects, as well as the increased energy users feel. Increases in norepinephrine/noradrenaline cause increased heart rate and blood pressure while increases in the serotonin system cause changes in mood, appetite, sexual arousal, and sleep cycles. Spikes in serotonin after taking MDMA likely account for the common feelings of emotional closeness and empathy. Buy XTC pills Australia
TOXICOLOGY
Potentially fatal neurological complications can occur following MDMA ingestion, likely due to short-term hypertension and dehydration that the drug induces. Buy MDMA New Zealand
Many fatal cases are due to abnormally high doses, prior health complications, a “bad batch,” or a combination of all of these. In fatal cases, necrosis of the liver and heart tissue have also been reported.[9] It’s often difficult to tell exactly how much of a role XTC (ECSTASY) plays in adverse reactions because, in these cases, people are more likely to have used multiple drugs.[10] As with any substance, MDMA should be used in moderation. Frequent use correlates with more complications than occasional use. Buy MDMA Belgium
Clinical studies with pure MDMA have been conducted on more than 1,100 individuals without the occurrence of severe adverse effects. Buy MDMA Sweden
MDMA EFFECTS BY DOSE
NOTE: Effects listed here aren’t meant to be comprehensive, particularly at the lower dose ranges. They may be subject to change as more reliable, more widely representative data become available. These dose ranges are intentionally conservative to account for the high variability of MDMA purity. They assume 100% (aka 84%) purity. Buy MDMA Austria
MICRODOSE MDMA (5-40 mg)
Microdosing MDMA (ECSTASY) is not as common as LSD and psilocybin, but with the general rise in interest in microdosing, some have wondered if the practice could enhance their moods and boost their energy. While some people have reported success with an MDMA regimen, we do not recommend it. There is a lot of evidence to suggest that frequent MDMA use can be very bad for you. After all, MDMA is not like classic psychedelics; it’s an amphetamine and a stimulant that does very different things to your body than a tab of LSD. Common effects may include: Buy MDMA Norway
- Slight mood enhancement, if at all
- Emotional vulnerability (opened to emotional content without anxiolytic effect)
- Disrupted sleep
- Extended comedown or hangover
- Mood disorders can be negatively effected
- Potential for heart issues
MODERATE MDMA DOSE (80-150 mg)
This is the most common dose for an MDMA experience and the dose used in clinical trials. In this range, users report the typical MDMA-associated sensations: euphoria, increased energy, empathy, etc. In this range, many people practice “re-upping,” which involves taking an initial 80-120mg dose, followed by an additional 40-80mg later on. This is the practice for MAPS’ clinical trials. Common effects may include: Buy MDMA Croatia
- Strong euphoria
- Therapeutic introspection
- Heightened self-esteem
- Openness and self-forgiveness
- Heightened empathy and sociability
- Increased energy
- Enhanced tactile, visual and auditory senses
- Dry mouth
- Jaw clenching/grinding
- Insomnia
- Possible next-day comedown effects, e.g. fatigue, depression (can also be felt over the next seven days)
HEAVY MDMA DOSE (200+ mg)
Even with tolerance, it may be unsafe to take more than 120mg of high-purity MDMA (or 1.5-1.7 mg/kg body weight, whichever is lowest). Positive effects appear to be maximized and negative effects are minimized between 81-100mg, ideally taken no more than once a month. Heavy doses of high-purity MDMA are potentially life-threatening, regardless of tolerance. Buy MDMA Denmark
- Strong euphoria
- Therapeutic introspection
- Heightened self-esteem
- Openness and self-forgiveness
- Heightened empathy and sociability
- Increased energy
- Enhanced tactile, visual and auditory senses
- Possible open-eye visuals or hallucinations
- Agitation and paranoia
- Panic
- Dizziness
- Headaches
- Nausea and vomiting
- Shivering/trembling
- Dehydration
- Jaw clenching/grinding
- Insomnia
- Seizure
- Next-day comedown effects, e.g. fatigue, depression (can also be felt over the next seven days)
MDMA INTERACTION WITH OTHER DRUGS
Positive interactions: Buy MDMA Romania
- Mushrooms: Known as “hippie flipping,” mixing psilocybin with MDMA is a popular combination. While mixing MDMA with any drug is not generally not recommended, this combination can be enjoyable and enhance aspects of both substances, particularly euphoria. The downside is that if the timing is off, the MDMA comedown could alter your mood for the last hours of your mushroom journey.
- LSD: Much like with psilocybin, combining LSD and MDMA (known as “candy flipping”) has its pros and its cons. With the MDMA can turn up the volume on the more psychedelic aspects of LSD, the comedown of this combination can be even more challenging than with mushrooms. It’s key to get the timing of the ingestion right.
- Ketamine: Another common combination, many users of the “kitty flip” also say that it brings out the best of both drugs. Buy MDMA Romania
Neutral interactions:
- Cannabis: Many people use cannabis to mitigate the comedown effects of MDMA (ECSTASY). This may be one of the least risky combinations.
Negative interactions:
- Alcohol: Because the liver metabolizes both drugs, combining the two can cause a buildup of MDMA in the body—metabolizing alcohol slows the removal of MDMA from the body. This can lead to stronger adverse reactions and more serious side effects.
- Drugs to be avoided include:
- MAOIs (e.g. Nardil, Parnate, Marplan, Ayahuasca)
- 5-HTP
- St. John’s wort
- Heart rate or blood pressure medications
- Stimulants such as cocaine
- Amphetamines
BENEFITS OF MDMA
While MDMA is known for giving rise to feelings of euphoria and general well-being, the benefits of the drug extend beyond several hours of bliss—it holds the potential to heal trauma, anxiety, disconnection, and possibly more. A recent study that looked at MDMA’s effects on the brain found that this healing could come from the drug’s ability to decrease activity in the brain’s limbic system and reduce communication between the temporal lobe and prefrontal cortex, both of which are involved in emotional control and response. People with anxiety see an increase in activity in these areas, suggesting that MDMA can help alleviate related mood disorders. Buy MDMA Ireland
MDMA (ECSTASY) also increases communication between the amygdala and the hippocampus, according to the study. People suffering from PTSD, on the other hand, see a reduction in communication between these areas. Buy MDMA Finland
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Another recent study by Dr. Ben Sessa found that MDMA could also be the best intervention to treat acute childhood trauma by offering people safe access to their emotions. “In combination with psychotherapy, [MDMA] provides the capacity to hold the traumatized patient in a state of emotional security, providing a state of empathic self-reflection,” Sessa writes, adding that, “for the first time in their lives, they can be with their traumatic memories without being overwhelmed by the powerful negative effect that usually accompanies recall of their most frightening thoughts.” This empathic self-reflection is also one of the reasons MDMA is proving to be such an effective treatment for PTSD. Buy MDMA Luxembourg
MDMA is also known for fostering a greater sense of connection and empathy in users, making it a strong antidote to feelings of distance and disconnectedness, particularly between couples. Relationship therapists are starting to use the drug in their sessions to help couples enhance communication, heighten intimacy, and reconnect. It’s not called “the love drug” for nothing. Buy MDMA Czechia
RISK OF MDMA
Adverse physiological effects can occur after ingesting MDMA (ECSTASY), including elevated blood pressure and heart rate, nausea, chills, sweating, tremors, jaw clenching, hyperreflexia, urinary urgency, muscle aches or tension, hot and cold flushes, nystagmus (a condition in which the eyes make repetitive, uncontrolled movements), and insomnia. At higher doses, these physiological changes can result in severe adverse reactions. Buy MDMA Albania
MDMA overdoses can and do kill. A high dose can be a contributing factor in deadly conditions such as hyperthermia, exhaustion, or hyperhydration. Additionally, it can trigger serotonin syndrome, or too much serotonin, which can cause muscle rigidity, fever, seizures, and more. Buy MDMA Iceland
Some people report an unpleasant comedown including feelings of depression and fatigue after a night of heavy MDMA use. In our microdosing course, Dr. Ben Sessa explains how the typical MDMA comedown is due to overexertion, poor sleep, poor diet, and polydrug use. As such, the comedown can be countered by eating and sleeping well before and after taking MDMA, keeping hydrated if you’re dancing, and avoiding other substances (including alcohol). Buy MDMA Malta
Recent research also shows that patients in clinical trials tend to experience an MDMA “afterglow” rather than a comedown, suggesting that pure MDMA alone does not produce these effects. Most adverse side effects can be attributed to adulterated MDMA, or “ecstasy,” which is often mixed with ephedrine, dextromethorphan, bath salts, cocaine, or methamphetamine. 87% of the ecstasy analyzed by the DEA between 2009 and 2013 contained no MDMA and was composed mostly of bath salts. Buy MDMA Hungary
The MDMA (ECSTASY) itself is not addictive, but due to the highly addictive nature of methamphetamines, some people may become addicted to impure forms of MDMA.
BUY MDMA PILLS ONLINE
The prohibition of MDMA in most countries (and especially the police seizures of safrole in 2008/2010 interrupting the supply of ecstasy) has led to the emergence of certain alternatives. These substances, about which we know relatively little, tend to be far more dangerous than MDMA itself. And yet they’re legal by default in many jurisdictions. Buy MDMA Cyprus
Following the procedure for making MDMA with aniseed oil instead of safrole, for example, yields not ecstasy but the problematic substances para-Methoxyamphetamine (PMA) or para-Methoxy-N-methylamphetamine (PMMA).[13] Both have been implicated in the deaths of unsuspecting users from as early as 1993.[14] In December 2014/January 2015, for instance, at least three individuals died after taking the same pink “Superman” pills containing PMA. Buy MDMA Bulgaria
PMA/PMMA can be 10 to 20 times more potent than MDMA, putting users taking a “safe” dose of what they believe to be ecstasy at risk of massively overdosing on a far more dangerous substance. [15][13] PMA/PMMA are also slower-acting, which means experienced ecstasy users are likely to re-dose too soon. Buy MDMA Slovenia
The trouble is, PMA/PMMA are not MDMA analogs. They have a different pharmacological action. Unlike MDMA, they block certain enzymes (e.g. monoamine oxidase, or MAO) that offset the release of serotonin. As a result, they can lead to serotonin syndrome, a potentially deadly overload of the body’s serotonin levels.[13][14] While reagent testing can help to identify the presence of PMA/PMMA, the presence of real MDMA could disguise the presence of PMA/PMMA as adulterants. Checking pills against user reports online (such as EcstasyData.org and Pill Reports) is therefore a sensible precaution. Buy MDMA Estonia
PTSD
In 2017, MDMA (ECSTASY) was approved for use in Phase III clinical trials in the US to treat post-traumatic stress disorder (PTSD). [16][17] This is one of the last phases of testing before a drug is legally approved for therapeutic use. The FDA granted MDMA “breakthrough therapy” status in 2017 and the drug is on the path to full FDA approval. Buy MDMA Slovakia
The trials are being funded by MAPS, which began studying and advocating for the use of MDMA to treat PTSD in 1986. Though the organization supports other psychedelic therapies, including LSD and psilocybin, they chose to focus on MDMA based on the fact that it is “the gentlest psychedelic,” according to MAPS founder Rick Doblin, as well as “the perfect drug for treating PTSD.” Buy MDMA Montenegro
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Research is backing this up. In a pilot study conducted by MAPS involving 20 patients with PTSD, the placebo group showed only a 25% response rate to the therapy (2 of 8 patients). Meanwhile, the MDMA group had an 83% response rate (10 of 12 patients). Following the treatment, nearly all of those who had received MDMA before psychotherapy no longer met PTSD criteria. The study also found no evidence of harm to patient health from a single session. Perhaps most remarkably, a long-term follow-up study found that 74% of the patients who had relieved their PTSD symptoms in the first study remained PTSD-free years later. Buy MDMA Lithuania
In a later Phase II trial, researchers found that 54% of the 72 patients who underwent MDMA-assisted psychotherapy no longer fit qualified as having PTSD (compared with 23% in the control group). A year later, that number had risen to 68%. Buy MDMA Andorra
There are many theories around why MDMA is proving to be such a strong antidote to PTSD. According to Doblin, there are two main reasons: MDMA reduces fear (PTSD stems from fear) and it promotes therapeutic alliance, or the relationship between patient and therapist, which is one of the most important factors in a patient’s recovery. Additionally, MDMA activates and quiets key parts of the brain associated with reductions in anxiety, depression, and trauma. Buy MDMA Belarus
Many patients who undergo this therapy are war veterans with a treatment-resistant form of PTSD. They report that MDMA therapy helped them approach their past trauma with a greater sense of acceptance, warmth, and compassion for themselves, allowing them greater opportunity to cope and heal. Buy MDMA Latvia
ANXIETY
Preliminary results from a few studies suggest MDMA is also a promising treatment for social anxiety in individuals with autism and life-threatening illnesses.[18] In the first clinical trial investigating MDMA for people with autism, 12 individuals were given MDMA or a placebo during two all-day therapy sessions. Among those who took the drug, 91% of participants reported “increased feelings of empathy/connectedness” and 86% experienced “ease of communication” during their sessions, which persisted after use. Buy MDMA Monaco
It’s thought that this success is due to MDMA’s ability to shift patients with social anxiety toward openness and encourage introspection, which can be accomplished with infrequent or even single doses of the XTC (ECSTASY).
This same mechanism also appears to operate in treating patients with life-threatening illnesses who experience clinical anxiety.[19] MAPS is currently conducting a Phase II trial to explore this area of MDMA’s potential. Buy MDMA Vatican City
ALCOHOL USE DISORDER
In 2017, Ben Sessa launched the first clinical trial examining the efficacy of MDMA in treating alcohol addiction. An illness often associated with early traumatic experiences, Sessa believes that MDMA is ideal for helping patients explore and address painful memories without being overwhelmed by negative reactions—much the way MDMA works for PTSD. “We know that MDMA works really well in helping people who have suffered trauma and it helps to build empathy,” Sessa said. “Many of my patients who are alcoholics have suffered some sort of trauma in their past and this plays a role in their addiction.” Buy MDMA Moldova
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PERSONAL GROWTH
SPIRITUAL AWARENESS
Though a connection to the spiritual realm is more often associated with classic psychedelics such as LSD and psilocybin, for many, MDMA is also a tool for spiritual growth. Some spiritual leaders and guides laud the drug’s ability to induce feelings of oneness, interconnectedness, empathy, compassion, warmth, and kindness toward others. States such as these are often catalysts for spiritual epiphanies and personal development. Buy MDMA San Marino
As the Benedictine monk Brother Bartholemew put it:
“MDMA always propels me into an intimate space in conversation. There is a special quality to this conversation. One feels a heaviness, a sense of the weight of the moment, of something profound, of the seriousness of life itself. It is a space that is inner, without masks, without pretense, utterly open and honest. It is not an erotic intimacy, but a philosophical and mystical intimacy. Does this make any sense? One has the consciousness that this is an inner communication rarely achieved in ordinary discourse. There really are no adequate words to express this state of awareness, only to say, that it is essential in my experience.”
MDMA can be used in many sets and settings to invoke spiritual development, from quiet introspection to meditation in groups to therapy. Even rolling at raves can have a spiritual quality if approached with the right intention. Buy MDMA North Macedonia
RELATIONSHIPS
MDMA is also proving to be a useful tool for building or repairing relationships. Relationship therapists are beginning to use the drug in their sessions to help couples enhance communication, heighten intimacy, and reconnect. Its use in relationship work dates back to the 1970s when a group of unorthodox therapists inspired by the work of psychopharmacologist and MDMA advocate Alexander Shulgin used MDMA to help partners foster empathy and communication. The practice is gaining popularity again due to the MDMA’s ability to “facilitate the psychotherapeutic process by helping people feel safer and more connected to themselves, to each other, and to their therapist,” according to MAPS’ Brad Burge. Buy MDMA Kosovo
Katie Anderson, a British doctoral researcher who is completing a Ph.D. on the topic of “navigating intimacy with ecstasy,” has deemed this increased connection between two people the “MDMA bubble.” In it, couples find a safe space to have their thoughts heard and accepted. Her research has seen couples expressing sexual fantasies, the pain of losing a parent or even confessing to affairs. As one respondent put it: “I think we keep ourselves protected, we don’t want to get hurt. But when you’re taking the drug, it allows you to take down those walls and just be open to somebody.” Buy MDMA Faroe Island
LEGALITY
BRIEF HISTORY
MDMA’s history began decades before the rave culture that popularized it. A common myth is that it was first synthesized and patented by the German pharmaceutical company Merck as an appetite suppressant. Merck did synthesize the drug in 1912, but the appetite suppressant story is an urban legend. It was developed as a potentially life-saving blood-clotting medicine. Buy MDMA Gibraltar
Minimal testing was done in the early years after its synthesis. It was not until 1927 that Merck revived interest in the drug after chemist Max Oberlin predicted that it might mimic adrenaline since the chemicals shared a similar molecular structure. Not long after these initial studies began, the prices of chemical precursors skyrocketed, and testing was put on hold. Buy MDMA Aland Islands
While no one knows precisely when the first human trials were conducted, the US military is known to have tested MDMA and other drugs on humans in the 1950s. The first “recipe” for MDMA was published in a Polish-language scientific journal in 1960 and tablets began popping up in seized contraband in the 1970s. Buy MDMA Svalbard and Jan Mayen
When American psychopharmacologist Alexander Shulgin first read about MDMA in 1978, he synthesized it and tried it himself, becoming the first person to officially record MDMA use in a human subject.[24] In the 1980s, its use in assisted psychotherapy was said to increase patient self-esteem and facilitate therapeutic communication. Buy MDMA Jersey
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While Shulgin is often called “the Godfather of Ecstasy,” MDMA’s actual creator was a German scientist named Anton Kollisch, who died in 1916 never knowing the legacy he left. Buy XTC pills
Since 1985, the drug has been listed as a Schedule I drug in the US, making it effectively illegal for all uses. However, clinical trials have been approved and conducted in recent years, and in 2017, the FDA granted MDMA “breakthrough therapy” status. It’s thought that the doctors could be prescribing the drug as early as 2022. Where to buy XTC pills
In 2011, a federal court sided with the ACLU, which argued that punishments for MDMA possession and use were based on outdated science that led to severe prison sentences[26]. However, other courts have upheld the previous sentencing laws. Buy molly pills
CURRENT USE
The annual National Survey on Drug Use and Health found that MDMA had been used at least once by 13.1% of people between the ages of 18 and 25, and 6.5% of people age 26 and over. Buy ecstasy pills
Time Period | Ages 12 or Older | Ages 12 to 17 | Ages 18 to 25 | Ages 26 or Older |
Lifetime | 6.80% | 1.40% | 13.10% | 6.50 |
Past Year | 1.00% | 0.80% | 4.10% | 0.50 |
Past Month | 0.20% | 0.10% | 0.90% | 0.10% |
These trends appear to be holding relatively steady:
18 to 25-Year-Olds | 26 Years Old and Over | |||||
Time Period | 2013 | 2014 | 2015 | 2013 | 2014 | 2015 |
Lifetime | 12.80 | 12.00 | 13.10 | 6.40 | 6.40 | 6.50 |
Past Year | 4.00 | 3.50 | 4.10 | 0.50 | 0.50 | 0.50 |
Past Month | 0.90 | 0.80 | 0.90 | 0.10 | 0.10 | 0.10 |
Its appearance in published reports and literature reached a peak in the early- to mid- 2000s and has fallen quite a bit since then: Buy mdma crystal
MYTHS
“Ecstasy will make me drink so much water that I’ll die”
Although one infamous ecstasy-related death was caused by overhydration, MDMA itself will not make you drink yourself to death. The victim in this case thought that by drinking a large amount of water, she would counteract an unpleasant ecstasy experience. Unfortunately, because MDMA also makes it harder for the body to process water, she died from water retention. Buy mdma powder
This doesn’t mean you should avoid drinking water when you’re on MDMA (ECSTASY). Taking a very high dose can cause an inability to regulate your hydration, so you should make sure you’re drinking water regularly – especially if you’re dancing or exerting yourself. Buy MDMA Canada
The main cause of MDMA-related deaths is a lack of education. People don’t know how to take the drug safely and end up increasing their health risks. When used responsibly, it is a relatively safe drug. Buy XTC pills Canada
“MDMA is a club drug only”
Although MDMA is very popular for use in clubs due to its enhancement of music and dance, that doesn’t mean it’s exclusively a clubber’s drug. Many people take it in a spiritual or therapeutic context. It can be used for various forms of personal and relationship development, and clinical trials are using it to treat sufferers of post-traumatic stress disorder, anxiety, addiction, and more. Buy molly pills New Zealand
“MDMA puts holes in your brain”
There is no evidence that moderate use (less than 100mg every few weeks) can cause damage to your brain.
Frequent high dose use can cause heart problems and memory problems. Additionally, it’s relatively easy to overdose on MDMA if it’s combined with other drugs, especially PMA/PMMA. MDMA overdose can be lethal.
FAQS
WHERE CAN I BUY MDMA?
MDMA stands for 3,4-Methylenedioxymethamphetamine. It’s one of the world’s most popular psychedelics (though technically it’s an empathogen). Until recently it was seen as more of a “party drug” than LSD or psilocybin. But it’s currently re-emerging as a breakthrough psychotherapeutic aid.[27] Researchers are especially enthusiastic about its potential for PTSD treatment.
It comes in two basic forms: tablets (or pills), which are often called “ecstasy,” and crystals (or powder), often called “Molly.”
Can I test my MDMA to see if it’s safe to take?
Testing your MDMA is always good practice even when you trust your supplier. Reagent test kits from Bunk Police can identify hundreds of adulterants and substitutes—offering peace of mind and potentially saving your life.
DXM, MDA, methamphetamine, methylone (“bath salts”), and PMA/PMMA are some common imposters to beware of. The Marquis, Mecke, and Simon’s reagents can help to rule them out. Simply place a tiny amount of MDMA into a sterile test tube or onto a sterile white ceramic surface and add a few drops of the reagent. Then check the color change (or lack thereof) against the supplied spectrum booklet.
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It is a type of amphetamine, a stimulant class of drugs that includes speed and methamphetamine. But MDMA is considerably more benign. As an amphetamine, it’s also part of the phenethylamine class of substances, like mescaline. Of course, the effects are substantially different. Based on these, MDMA may be classified as an entactogen or euphoric empathogen.
WHAT DOES MDMA DO?
Regardless of dosage, it’s a stimulating drug. Most people report physical and emotional euphoria, along with mild visual effects, such as color enhancement. Increased stamina (e.g. for dancing) is also common.
Side effects include increased perspiration, dehydration, jaw clenching, and involuntary shaking.[28]
HOW DO I TAKE MDMA
MDMA may be ingested as an oral tablet or in crystal or powdered form, which can be taken orally or insufflated (snorted). Snorting MDMA tends to be unpopular, however, because of the bad flavor, potential for nose bleeds (as well as anxiety and palpitations), and the relatively short-lived effects. Many people mix the crystal into their drinks to avoid the bitter taste. Smoking or vaping is another option, but it’s even less popular than snorting.
Effects will take up to an hour to appear. Don’t redose too frequently. Don’t mix with other drugs.
How long does MDMA last?
The effects last for three to six hours. You should begin to feel them 20 to 90 minutes after dosing. The peak itself may last anywhere between 90 minutes and three hours before diminishing over the following one to two hours.
After the primary effects have worn off, you may experience a “comedown” or post-trip “crash” characterized by feelings of depression and fatigue. These can be mild or severe and may last between 12-72 hours, or possibly up to a week.[28][29]
What about the purity of crystal/powder MDMA?
Despite what you may have been sold, even in crystal or powder form, pure MDMA is difficult to find on the street. However, as previously noted, street MDMA concentration has been climbing in recent years. In the UK, at least, it has apparently reached 83%.[30] This is pretty much the maximum purity that’s available.[31]
MDMA in pure form has by definition a purity of 100%. Unfortunately, whatever form it’s in, a sample is unlikely to be pure. There’s probably something else in it—and adulterants can be deadly. Using a test kit is a good precaution. These can identify the presence of MDMA as well as toxic adulterants by a color change you can check on a chart. However, chemical reagent tests cannot tell you the purity; they’re only indicative at best. They should, therefore, be used alongside other harm reduction practices.[32]
How long does MDMA stay in your system?
Like other amphetamines, it stays in the system for 24-96 hours after use, with 72 hours being the average.[33]
Can it be detected in a drug test?
MDMA is structurally close enough to amphetamines to return a positive result in standard urine drug screens up to five days after use. It is also detectable in hair samples for up to 90 days.[33]
Does it produce tolerance?
MDMA depletes serotonin levels, so users often experience a “hangover” lasting up to a few days, during which they may feel depressed or mentally exhausted. Therefore, expect an MDMA tolerance to last for several days.
It’s best to avoid taking MDMA more than once a month, as long-term use can be neurotoxic and affect memory and mood.
Is it addictive?
According to the National Institute on Drug Abuse, studies have so far failed to definitively answer this question.[34] However, most people who actually use MDMA find it to be non-addictive.[35]
Can I mix it with other drugs?
MDMA should not be mixed with other drugs, as some combinations can be dangerous. Since it affects the kidneys and liver, it’s best to avoid combining it with alcohol. You should also avoid mixing it with DXM, tramadol, and MAOIs, as these combinations can be fatal.
The best way to take MDMA is without any other drug, and with plenty of water if you’re dancing. This should help to minimize health risks.
Can I microdose with MDMA?
Some people have reported microdosing MDMA, but it’s possible that long-term use can be toxic. It depletes serotonin levels, and microdosing could leave you with a long hangover. MDMA should be used once a month at most to avoid any dangers of long-term neurotoxicity.
MDMA is just as useful in psychotherapy as it is as a recreational party drug. It’s used to foster a greater connection between two individuals and break down some of the barriers that get in the way of confronting mental health issues.
There’s also been a lot of exciting research developing around the use of MDMA as a clinical tool for mental health conditions like PTSD, anxiety, depression, and much more.
In this guide, we’ll take a deep dive into the world of MDMA. We’ll cover how it feels, how much to take, information on safety, and what changes are likely coming soon from a legal perspective.
MDMA VENDORS
MDMA (3,4-Methylenedioxymethamphetamine) is a synthetic drug in the amphetamine class of compounds. It’s often referred to as ecstasy, molly, or X.
The man who popularized MDMA, Alexander Shulgin, first described the drug under the name Window for its ability to strip away our habits and biases — allowing us to see the world more clearly. He believed it would become important in the field of psychotherapy.
He wasn’t wrong.
MDMA was used as a tool by health practitioners as a way to help break down barriers in their patients’ psyche to uncover deeply rooted traumas, foster a stronger patient-practitioner connection, and give patients the ability to take an unbiased look at their life and their emotions to better understand the root of their pain and suffering.
It was considered an important therapeutic drug for the treatment of PTSD, anxiety, depression, and other mental health disorders throughout the 1970s and 80s. After the substance leaked from the clinic and started circulating around in the mainstream public, it was promptly banned and removed from practice.
Only recently has MDMA started to regain its reputation in the medical setting with the development of the expanded access program and an increasing number of promising research programs over the past couple of years (more on this later).
Today, approved clinics are using MDMA in the treatment of PTSD, depression, and couples therapy for its ability to break down biases and promote a sense of empathy and connection between people.
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Chemical Name | 3,4-Methylenedioxymethamphetamine |
Level of Risk | Moderate |
Street Names | Ecstasy, X, Molly |
Most Common Side-Effects | Dehydration, Agitation, Excessive sweating, Hyperthermia, Jaw clenching |
Duration of Effects | 4–6 hours |
Legality | Illegal worldwide |
SAFE MDMA GUIDELINES
- 🐍 I understand why psychedelics should be treated with respect
- ⚖️ I’m familiar with the laws for MDMA in my country & state
- 🍄 I’m familiar and confident in the dose I’m taking (50–150 mg)
- 🧪 I’ve tested a sample of the substance I’m using with a drug testing kit
- 💊 I’m not mixing any medications or other substances with MDMA
- 🏔 I’m in a safe & comfortable environment with people I trust
- 🐺 One of the members of my group is responsible and sober (AKA a trip sitter)
- ⏳ I have nothing important scheduled for after the trip
- 🧠 I’m in a sound & healthy state of mind
- ❤️ I don’t have any underlying health issues — don’t take MDMA if you have underlying heart, neurological, or psychiatric disorders
- 👭 Use the buddy system — MDMA can remove your inhibition and allow you to make unsafe decisions, always stay with people you trust, and never go out alone
- 🌵 I understand the risk of dehydration — it’s easy to become dehydrated on MDMA, so make sure you’re drinking a cup of water every hour while using molly
- 🦻 Protect your hearing — music can be intoxicating while on molly, but protect your hearing and bring ear protection before you go out to a club or concert
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The MDMA experience is usually very positive in nature — unlike other psychedelics, which are highly susceptible to the people and environment you spend your time in throughout the trip.
The euphoric effects of MDMA make it less likely for you to experience challenging or scary experiences during the trip — but it’s not impossible.
The effects of MDMA usually begin about an hour after taking the substance. It tends to peak quickly, within about an hour after the effects first start to appear.
You’ll feel a greater sense of euphoria, pleasure, social bonding, connection with the people around you, and your perception of sights and sound will change. MDMA is not a hallucinogen in the traditional sense, but it can make lights and colors appear more vibrant.
The MDMA experience is intensely emotional. Users often feel the desire to hug or touch others, they may feel intense emotions of love and admiration surface towards friends and family, and they may feel a sense of arousal and enhanced sexual desire.
In total, the effects of MDMA last between 4 and 6 hours.
Ecstasy tablets that have been adulterated with other substances may have different effects and may last for a longer or shorter duration overall.
MDMA DOSAGE
The usual dose of MDMA is between 50 and 150 mg. Most people take a dose of 100 mg.
The dose of MDMA can vary depending on factors such as your size, how much food you’ve eaten prior to the session, and your experience using MDMA or other stimulants. Ecstasy is very unreliable as well — some tablets are substantially stronger than others, so even if you’ve used two or three tablets in the past, it’s not wise to assume a new tablet is going to have the same dose.
One of the easiest ways to overdose on MDMA is to take too much because you waited an hour, decided it wasn’t strong enough, and took another. Eventually, both tablets will take effect, and it may be strong enough to result in an overdose.
It’s wise to start with a lower dose for your first session (less than 100 mg) and only take a higher dose if you’re familiar with how the tablet feels and how your body responds.
MICRODOSING MDMA
Microdosing is a practice that involves taking a dose of a substance that’s too small to feel the effects.
The most common substances people microdose are psychedelics like LSD or magic mushrooms, but some people are microdosing MDMA as well with the goal of improving focus, concentration, creativity, and connection with others.
It’s sometimes used by couples to experience a deeper level of closeness and sexual intimacy.
The usual microdose of MDMA is between 5 and 10 mg per day.
The dose should be taken in the morning to allow it to wear off by the time you’re ready to go to bed. Taking your microdose of MDMA too late in the day could make it difficult to fall asleep.
There are some (theoretical) concerns about using MDMA for long periods of time — even in microdoses.
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This compound has a particularly high affinity for activating the 5HT2B receptors — which is a subset of serotonin receptors found primarily in the brain and heart. It’s thought that activating these receptors too much with repeated doses of MDMA could lead to the development of heart valve disorders. This concept first appeared in 2012 after a study was published that found 8 out of 29 patients that were regular users of ecstasy had heart valve defects [5]. The control group (non-MDMA users) had no signs of heart valve defects.
This effect has yet to be proven or disproven, so until more research is available, it’s wise to limit your microdosing of MDMA to just a few days at a time with longer break periods in between.
Many MDMA advocates suggest a different approach — taking what’s called a threshold dose of MDMA instead and spreading the doses out over weeks or months. A threshold dose sits somewhere in between a microdose and a standard psychoactive dose. It’s defined as the minimum dose needed to produce noticeable effects.
For MDMA, the threshold dose is usually around 30 mg. People use it as frequently as once per month or once every few months.
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The effects of MDMA usually appear around 20–60 minutes after taking the dose and last up to 6 hours.
The duration of effects depends on what other ingredients may be included in the powder or tablets you’re using. It’s exceedingly rare to find ecstasy tablets that contain pure MDMA these days. Some ecstasy tablets can last up to 10 hours; others have a much shorter duration.
What is MDMA-Assisted Psychotherapy?
Psychedelic-assisted psychotherapy is the practice of using psychedelic substances (including MDMA) to treat specific mental health disorders.
MDMA-assisted psychotherapy was a common practice in the 70s and 80s but was banned for the past four decades. Only recently has this practice started to pick up where it left off thanks to the efforts of MAPS (the Multidisciplinary Association for Psychedelic Studies) and their research on the therapeutic role of MDMA for various medical disorders.
Today, MDMA is still considered a Schedule I drug in the United States — which implies the drug is highly addictive and has no medical value. Despite this, there’s been a big push to bring MDMA back into the medical system through an Expanded Access Program.
The focal point of MDMA-assisted therapy at the moment revolves around the use of the substance for PTSD. This comes after a statement from the FDA that MDMA is a potential “breakthrough therapy” for treating PTSD. MAPS then set out to conduct a new phase 3 clinical research program to further legitimize the use of MDMA for this application.
Most of the clinics currently awaiting approval for the expanded access program aim to use the MDMA for the treatment of patients diagnosed with PTSD.
There are plenty of other medical applications of MDMA, however — with research supporting the use of MDMA for eating disorders, addiction, alcohol abuse disorder, existential depression, and more.
MDMA-assisted psychotherapy for PTSD is expected to cost around $15,000 — which is about the average cost of conventional PTSD treatment over the course of several years.
MDMA FOR POST TRAUMATIC STRESS DISORDER
PTSD is a chronic mental health disorder that develops after a traumatic event. It can involve recurrent memories, nightmares, flashbacks, anxiety attacks, or a sense of impending doom.
Patients with PTSD often experience insomnia, anxiety, addiction, depression, irritability, or self-destructive behaviors alongside the condition.
The condition is very common — affecting roughly 8 million Americans every year.
MDMA is the most promising therapeutic option currently being explored in the treatment of PTSD.
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Of the 12 patients given MDMA and psychotherapy integration, 83% reported significant improvements in their condition. In the follow-up period after the trial, 83% of the patients that took MDMA no longer met the criteria for PTSD diagnosis. A three-year follow-up study reported that 74% of patients in the treatment group remained free from PTSD [4].
The outcome of this study was remarkable and prompted an immediate focus on the effects of MDMA for PTSD. Current medical treatments for the condition are insufficient. The most common prescriptions for PTSD are benzodiazepine drugs like Xanax, Ativan, or Valium.
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A recent meta-analysis reviewed 18 studies on the use of benzodiazepines for PTSD (including over 5200 patients) found no evidence to suggest these medications are effective for treating PTSD [3]. In fact, there was even evidence to suggest it might make symptoms worse.
We’re in dire need of effective treatment protocols for this condition.
This is one of the main drivers for the development of the expanded access program that allows patients and practitioners access to MDMA for the treatment of PTSD and related mental health disorders.
MAPS is currently performing a phase III clinical trial exploring the effects of MDMA for post-traumatic stress disorder.
Make sure to subscribe to our newsletter to stay up to date on the developments in the psychedelic space as the results of this research become available.
Suggested Reading: Can Psychedelics Heal Trauma?
2. MDMA For Social Anxiety Disorder In Autistic Adults
A double-blind, placebo-controlled pilot study found a rapid improvement in symptoms of social anxiety in autistic adults [1]. Experimental sessions were spaced one month apart and consisted of 2 8-hour treatment sessions (either 75-125 mg MDMA or placebo) — followed by three non-drug psychotherapy follow-up or integration sessions.
This study used the Liebowitz Social Anxiety Scale (LSAS) to measure the severity of anxiety before the trial and after each session. Scores were recorded again six months after the conclusion of the last experimental session.
The results of this study have been extremely positive — prompting much larger studies.
MAPS is currently raising funding to conduct a new study exploring the effects of MDMA-assisted therapy as a potential treatment for social anxiety disorder in autistic individuals. Currently, there are no effective treatments for managing social anxiety in this population.
3. MDMA-Assisted Couples Therapy
MDMA isn’t used in couples therapy at the moment — not in the United States at least. However, it was once considered invaluable for repairing disconnected or damaged relationships.
MDMA (or other chemical interventions) were especially useful for what we could call “gray” marriages — relationships that aren’t hateful or abusive, just unsatisfying. This can happen for a number of reasons — such as stagnation or dramatic differences in sex drive.
Therapists would administer MDMA to both parties. The couple would lay on a comfortable couch with eyeshades on and start talking whenever they were ready [11]. Sessions can last for several hours, and the therapist acted as both a catalyst and a mediator for the conversation. It was very common for there to be significant emotional breakthroughs after just a single session with MDMA.
MDMA works by decreasing irrational fear responses to perceived emotional threats.
What this means in basic terms is that it removes barriers that may be preventing couples from connecting and opening up to each other emotionally.
Emotional repression is one of the leading causes of relationship issues.
Using chemicals like MDMA to dissolve these repressive emotions is often enough to bring the couple back into harmony with each other.
There’s been a push towards bringing MDMA back into couples therapy along with the renewed interest in this chemical for its applications in other psychotherapies. MAPS is planning an upcoming clinical trial to explore the effects of MDMA-assisted therapy for post-traumatic stress disorder in couples.
As laws change and more research enters the public domain, we expect to see MDMA therapy become more readily available in the United States, Canada, and Europe once again.
What Does Expanded Access for MDMA Mean?
Currently, MDMA is only officially legal for use inside approved laboratories. It’s only permitted for research purposes — not therapeutic use.
The expanded access program (part of the “Compassionate Use Act”) gives access to the substance outside the lab. It’s designed to help licensed medical practitioners and clinics begin administering MDMA and other psychedelic substances to their patients with certain medical conditions.
MAPS recently submitted a protocol to the FDA to allow clinics to apply and undergo specific training on how to integrate MDMA into their practice. The training is projected to cost around $9,000 and provides accreditation for mental health clinics to begin using MDMA — pending approval by the FDA.
The first MDMA clinic is projected to open later this year in Oregon. The clinic — Somatic Center Portland will offer MDMA-assisted psychotherapy specifically for people suffering from PTSD.
How Strong is MDMA Compared To Other Psychedelics?
MDMA is technically classified as a psychedelic because it targets many of the same receptors used by conventional psychedelics like LSD, psilocybin, and DMT. Classical psychedelics focus on the 5-HT2C receptor, which is the main mechanism of action involved in producing visual and auditory hallucinations.
MDMA is a little bit different in that it focuses on the 5-HT2B receptor instead. This receptor isn’t strongly associated with changes in visual or auditory perception but has a strong impact on our feeling of connectedness, empathy, and emotion.
Overall, the effects of MDMA are much more stimulating than most psychedelics. It’s most similar to compounds like 2C-B or low-dose ketamine.
MDMA vs. 2C-B
2C-B is often described as a blend of MDMA and LSD in terms of its effects. While this is a good summary, the experience of both substances is distinct from each other. The overlap comes from the empathogenic effects of both substances. This means they create a sense of openness and connectedness with others MDMA (ECSTASY)
Low doses of 2C-B are the most similar to MDMA, but the effects differentiate at the higher doses.
MDMA remains focused on the empathogenic and stimulating effects in high doses, while 2C-B becomes much more psychedelic in nature.
Both substances are often used interchangeably at concerts, music festivals, or parties. Other related 2C-x compounds such as 2C-E and 2C-I share a similar overlap in effects with MDMA as well MDMA (ECSTASY)
MDMA vs. MDA
MDA (methylenedioxyamphetamine) is a close relative of MDMA. In fact, it’s one of the metabolites of MDMA that’s created by our liver as it metabolizes it into smaller pieces.
The effects of MDMA (ECSTASY) and MDA are very similar — both promote a sense of openness and connectedness, and both act as potent central nervous system stimulants.
The key differences between these two revolve around the focus of the experience.
MDMA (ECSTASY) produces much more of the “lovey” feelings, while MDA is slightly more psychoactive and stimulating. Most people who have used both substances prefer the effects of MDMA over MDA.
MDMA vs. Ketamine
The effects of ketamine are highly dependent on the dose used. Lower doses are used interchangeably with MDMA at concerts, clubs, and music festivals. It’s stimulating and promotes a sense of clarity, energy, and connection in a similar way to MDMA. The effects between these two substances are similar in that they have many of the same qualities — but they’re distinctly different from each other.
High doses of ketamine are very different. It becomes substantially more psychedelic in higher doses and can even lead to out-of-body experiences. Higher doses of ketamine are not ideal for use in loud, busy, or active environments at this dose and are completely different from the effects experienced under the influence of MDMA.
Some people choose to combine the effects of ketamine and MDMA together for a dissociated, but euphoric mind state. This practice is termed “kitty flipping.”
MDMA vs. Magic Mushrooms
MDMA and the active ingredient in magic mushrooms (psilocybin) target many of the same receptors in the brain — yet their effects are completely different.
Both magic mushrooms and MDMA (ECSTASY) produce changes in visual and auditory perception, promote introspection and a sense of connectedness, and last between 4 and 6 hours.
MDMA is significantly more stimulating than magic mushrooms and produces a dramatically more intense euphoric sensation. Mushrooms are much more visual in their effects and are more likely to lead to ego-death experiences than MDMA.
Some people like to combine the visual hallucinations of magic mushrooms with the euphoric and empathogenic effects of MDMA. The practice is commonly referred to as hippie flipping.
Most people start with magic mushrooms and take the MDMA (ECSTASY) at the peak about 2 hours into the journey
The comedown from MDMA (ECSTASY), while you’re still on mushrooms, can be very uncomfortable, so most people try to offset these substances, so the comedown happens once most of the magic mushroom effects have already worn off
IS MDMA SAFE?
MDMA has a low level of risk compared to most other recreational substances. An article published in the Lancet in 2010 compared and ranked the relative level of risk to consumers and society [10]. This study ranked MDMA (ECSTASY) as one of the least risky substances involved in the study.
Most cases involving adverse reactions with MDMA involve a combination of substances that go above and beyond just MDMA (ECSTASY) [12] — which makes it difficult to assess the true level of risk of using the drug in a recreational setting. People who experience the most issues with MDMA are the ones that use this substance the most [13]. As with any substance, moderation is key.
MDMA Adulteration
Adulteration is one of the main safety concerns involved with the use of MDMA. An analysis from EcstacyData.org conducted by FHE Health reported that the average concentration of MDMA in ecstasy tablets was just 30%. There are also plenty of samples that were found to contain 0% MDMA.
Dance Safe reported that only half the substances users thought were MDMA actually contained detectable levels of this compound after testing. Similar findings from seizures tested by the DEA reported that only 9% of samples actually contained this substance.
There are many different chemicals a manufacturer can use as an adulterant in their ecstasy tablets. Ingredients range from inert substances like magnesium citrate to potentially lethal drugs like fentanyl or PMA/PMMA.
It’s also common to find ecstasy tablets that contain methamphetamines or MDA instead — which are closely related to MDMA (ECSTASY) but have different effects.
The bottom line is that there’s more fake molly on the market today than there is real molly. Always test your MDMA (ECSTASY) yourself before you use it to make sure it actually contains MDMA.
At-home drug tests won’t tell you what else is in the sample — it will only be able to detect the presence or absence of specific compounds. They won’t tell you the purity of the tablets you’re using.
It’s most important to test the sample for opioids (there shouldn’t be any detectable levels of opiates) and check the sample for PMA and PMMA — which can be deadly, especially when used in combination with MDA or MDMA.
Common MDMA Adulterants Include:
- MDA
- Fentanyl (very dangerous)
- PMA/PMMA (very dangerous)
- Magnesium citrate or magnesium stearate (inert)
- Caffeine
- Ketamine
- DXM
- Cocaine
- Methamphetamines
- Synthetic cathinones (bath salts)
MDMA Drug Interactions
Compounds like MDMA (ECSTASY) that have a strong impact on the body bring a higher risk of interacting with other substances or medications.
There are three main ways drugs can interact with each other in the body:
- Agonistic interactions — These are drugs that have a similar set of effects. When combined, their effects become stronger and can lead to side effects.
- Antagonistic interactions — These are drugs that have conflicting effects and may counteract each other. If medications are counteracted, they may lose their effectiveness in treating medical conditions.
- Liver metabolism interactions — The liver metabolizes virtually all substances that enter the body. If two or more drugs require the same enzymes, the rate of metabolism can slow down, causing both drugs to build up in the system.
Antidepressant Medications
One of the key mechanisms of MDMA is an increase in both serotonin and dopamine activity in the brain.
Therefore, mixing MDMA with other drugs that alter serotonin or dopamine levels in the brain could result in side effects.
An example of substances that affect serotonin and dopamine include monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, and many others.
Heart Medications
MDMA may also interact with heart medications. This substance is a stimulant. It increases heart rate and blood pressure — which could interfere with heart medications designed to regulate blood pressure or heart rhythms. You should never take MDMA if you’re using heart medications of any kind or have underlying heart disease (including valve disorders).
Stimulant Medications
The stimulating action of MDMA can make it interfere with other stimulants — such as ADHD medications, caffeine, or nicotine.
Combining multiple stimulants could increase the chances of side effects like rapid heartbeat, high blood pressure, anxiety, or increase chances of heart attack or stroke.
Liver Metabolic Interactions
MDMA is largely metabolized by the CYP2D6 isoenzymes and is likely to interact with other drugs that rely on this metabolic pathway.
A few examples of common drugs that follow the same metabolic route include:
- Beta-Blockers
- Codeine
- Dextromethorphan
- Haloperidolv
- Many antidepressants
- Tamoxifen
MDMA Side Effects
All drugs and substances bring the risk of side effects. MDMA is no exception.
Most of the side effects of this substance stem from its stimulating effects. This includes increased heart rate, excessive sweating, high blood pressure, agitation, and jaw clenching.
Paired with the drug’s effects on cognition, many MDMA users overexert themselves (dancing for hours on end) and forget to eat food, drink water, or regulate body temperature. This can lead users to experience severe side effects like dehydration or hyperthermia — both of which can have severe consequences.
The most common side effects of MDMA include the following:
- Anxiety attacks
- Dehydration
- Dizziness
- Dry mouth or excessive thirst
- Excessive sweating
- Hyperthermia (heat stroke)
- Impaired judgment
- Jaw-clenching
- Muscle tension or weakness
- Nausea or vomiting
- Rapid eye movements
- Rapid heart rate or palpitations
- Tingling sensation in the skin
MDMA can also increase the risk of more serious health conditions — such as seizures, stroke, heart attack, dehydration, or heat stroke.
Does MDMA Cause a Hangover?
Some MDMA users report feeling hungover the following day after using MDMA.
The effects usually only last a day, but it’s not uncommon for the hangover to last up to 5 days.
Symptoms of an MDMA hangover can range from low mood or depression, dizziness, poor appetite, loss of libido, insomnia, or suppressed immune system.
The best way to minimize the severity of an MDMA hangover is to drink plenty of fluids, replenish your electrolytes, eat micronutrient-rich foods, and ensure you’re getting up to move around throughout the day.
Laying in bed all day, eating junk foods, and avoiding social interaction altogether all tend to make the MDMA hangover worse.
Is MDMA Addictive?
Any substance can become addictive — especially those that have a strong impact on our mood or sense of wellbeing. MDMA definitely fits into this category.
MDMA is not strongly addictive based on the traditional definition. It rarely leads to dependence or tolerance like other addictive drugs such as opiates or cocaine. A panel of addiction experts, psychiatrists, and epidemiologists used the Delphi method to rank the potential risk of 20 of the most common recreational drugs — MDMA ranked 18th on the list for the potential for dependence as well as the level of social and physical harm [8].
Most addictions involving MDMA are classified as behavioral or habitual addictions [6].
This means people use MDMA habitually while engaging in nights out with friends or for the positive impact the drug has on mood with mental health disorders.
MDMA can be physically addictive as well — it’s just much less common and generally takes a long period of time with consistent use to reach this point. Adaptations have been reported in the serotonin and dopamine receptors of the brain with long-term MDMA consumption.
One of the primary ways researchers assess the addictiveness of a substance is by giving mice doses of the drug and then observing other mice self-administer the substance again in place of food. Studies involving this experiment with MDMA have shown that mice will self-administer MDMA, but to a much lower extent than other addictive drugs like cocaine or heroin [7].
IS MDMA LEGAL?
MDMA is illegal in most parts of the world outside of research programs.
In the United States, MDMA is classified as a Schedule I illicit drug. Which suggests this substance is addictive and has no accepted medical use.
As more research becomes available proving that MDMA has legitimate health benefits. It’s very likely this substance will become available through approved health clinics or prescriptions.
The DEA recently classified MDMA as a “breakthrough therapy” for managing symptoms of PTSD. MAPS has also made a lot of progress towards bringing MDMA. To mental health clinics in the United States and Europe.
How Does MDMA Work?
MDMA activates several different receptor types to produce its effects [9]:
- 5-HT1A serotonin receptor agonist
- 5-HT2A serotonin receptor agonist
- 5-HT2B serotonin receptor agonist
- 5-HT2C serotonin receptor agonist
- α1, α2A, & β-adrenergic receptor agonist
- Dopamine (D1 & D2) receptor agonist
- Serotonin & dopamine reuptake inhibition
- M1 & M2-muscarinic receptor agonist
- Histamine (H1) receptor agonist
- TA1 receptor (TAAR1) agonist
Final Thoughts: What’s The Future of MDMA?
The laws on MDMA have remained very clear for the past 35 years — it’s highly illegal for any reason.
But recently, these laws have been challenged. An organization under the name of MAPS has been publishing robust clinical studies outlining the benefits of MDMA therapy. For the past few years that forced the FDA to acknowledge MDMA as a breakthrough therapy for PTSD.
MAPS even submitted a protocol to the FDA that, once approved, creates a pathway to allow mental health clinics and practitioners to begin employing MDMA (ECSTASY) as part of their therapeutic arsenal.
A similar change has been observed in the ketamine therapy space in recent years. As the research continued to build and strengthen, it became harder to deny the therapeutic benefits of the substance. There are now ketamine clinics located throughout the United States.
It’s very likely we’ll start to see similar improvements in the accessibility of MDMA (ECSTASY). Over the next few months or years.
With the push towards a more robust network of telehealth practitioners due to the pandemic. It’s possible we’ll even start to see companies like Mind Bloom step up to bring MDMA-assisted therapy online. With mail-in treatments and online integration sessions.
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