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WHAT IS SATIVEX?
Sativex is a cannabis-based medicine. It’s used to treat the common MS symptom of muscle stiffness and spasms (known as ‘spasticity’). Buy Nabiximols Germany
Sativex is a spray you use in your mouth. It contains two chemicals from the cannabis plant called cannabinoids. They’re in an equal mix of tetrahydrocannabinol (THC) and cannabidiol (CBD).
HOW DO I TAKE SATIVEX?
Nabiximols is a mouth spray (sometimes called an oromucosal spray) and you start off taking one dose a day. You then slowly add more doses until you get the most relief from your symptoms. You mustn’t take more than 12 doses of Sativex a day. Buy Nabiximols Norway
HOW WELL DOES SATIVEX WORK?
Sativex doesn’t work for lots of people. But for those it does work for, their spasticity symptoms get significantly better. When people use Sativex around 7 in 10 of them see their spasticity reduce by at least 20%. And spasticity is reduced even more for some people – by 30% or more for around 4 in every 10 people.
If your spasticity symptoms haven’t got better by at least 20% after 4 weeks, you usually stop taking it.
WHAT MS SYMPTOMS CAN SATIVEX HELP WITH?
Nabiximols only has a licence to treat spasticity but some people say it helps with their other MS symptoms, including: Buy Nabiximols UK
- bladder problems
- difficulty sleeping
- tremor (uncontrolled shaking of the leg or arm)
A 2014 study found the drug didn’t help with tremor, but that it was ‘probably effective’ for spasticity, pain and bladder problems. Buy Nabiximols Switzerland
CAN I GET SATIVEX
Nabiximols is now approved for use on the NHS in England, Wales, Scotland and Northern Ireland for some people with MS. It’s not recommended for people under 18.
In England, the National Institute for Health and Care Excellence (NICE) recommends which drugs you can get on the NHS. In 2019 it decided Sativex could be available to people in England with ‘moderate’ to ‘severe’ spasticity. This is only when other treatments haven’t helped. Buy Nabiximols Sweden
In Wales, Sativex has been available like this since 2014.
In Northern Ireland, Sativex was accepted in April 2021 by the Health and Social Care Board process for the Managed Entry of Medicines, again for use in people with ‘moderate’ to ‘severe’ spasticity when other treatments haven’t helped. Buy Nabiximols Austria
In Scotland Sativex was approved in September 2022 by the Scottish Medicines Consortium for use on the NHS, using the same criteria as elsewhere in the UK.
Wherever you live in the UK, it might still be difficult to get Nabiximols because the NHS in some regions might not agree to pay for it, or local prescribers decide not to give it to people. Buy Nabiximols Finland
The NHS in your specific region might not pay for it, or prescribers might decide not to give it to people. A doctor anywhere in the UK can give you a private prescription for Nabiximols. But this costs over £500 for a month’s supply. Buy Nabiximols Italy
There are some cannabis-derived drugs that are not yet approved in the United States, including Sativex, a combination spray of THC and cannabidiol. Sativex combines equal quantities of THC and CBD from two cannabis extracts. Buy Nabiximols Spain
Nabiximols is available on prescription in the UK, Spain, Germany, Canada, Denmark, Norway, Israel, Austria, Poland, Sweden, Italy and Finland with launches currently in preparation for a further eight European countries, as well as Australia, New Zealand and Kuwait. Buy Nabiximols Australia
However, to date, there is a lack of conclusive scientific evidence to prove that CBD is an effective arthritis treatment for humans. Evidence notes that a cannabis-based mouth spray called Sativex may help relieve arthritis pain.
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DOES SATIVEX TREAT MULTIPLE SCLEROSIS?
Sativex®, also known as Nabiximols, is an oromucosal spray comprising two chemical extracts – active cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) – derived from the cannabis plant. Buy Nabiximols Denmark
It is used for treating spasticity due to multiple sclerosis (MS), neuropathic pain and intractable cancer pain.
Nabiximols was developed by GW Pharmaceuticals, a UK-based pharmaceutical company. GW Pharmaceuticals was later acquired by Jazz Pharmaceuticals, a pharmaceutical company based in Ireland, in May 2021. Buy Nabiximols Hungary
GW Pharmaceuticals teamed up with several companies to support the development and commercialisation of the drug in different parts of the world. It collaborated with Otsuka for development in the US, with Almirall in Europe (except the UK) and Mexico. It collaborated with Novartis for development in Australia, New Zealand, parts of Asia, the Middle East (except Israel), and Africa and with Bayer for development in the UK and Canada. Ipsen covers Latin America (except Mexico and the Caribbean islands) while Neopharm handles Israel. Buy Nabiximols Israel
Subsequently, GW Pharmaceuticals dropped its licence deal with Otsuka for Nabiximols in the US in December 2017, reclaiming control of the product’s research and marketing rights without upfront payments. It also reclaimed the exclusive commercialisation rights to Sativex in the UK from Bayer in March 2020. Buy Nabiximols Ireland
Nabiximols is available in a 10ml vial containing up to 90 metered sprays. It is available as a spray solution for use as an oro-mucosal or buccal pump spray. The metering pump delivers 100 microlitres per spray. Each carton includes one, two, three, four, five, six, eight, ten, or 12 amber glass vials.
REGULATORY APPROVAL FOR SATIVEX
Nabiximols received regulatory approval for the treatment of neuropathic pain associated with MS in Canada in 2005. In August 2007, Canadian regulators approved Nabiximols as an adjunctive analgesic treatment in adult patients with advanced cancer pain. Buy Nabiximols Poland
Almirall submitted a regulatory application for Nabiximols for the treatment of MS spasticity in the UK and Spain in May 2009. The application was approved by the Medicines and Healthcare Products Regulatory Agency (MHRA) in June 2010. GW Pharmaceuticals received approval for Sativex for treating MS-related spasticity in Spain in July 2010. Buy Nabiximols Turkey
Sativex was approved by New Zealand’s regulatory authority MedSafe in November 2010.
The company announced the successful completion of the European Mutual Recognition Procedure (MRP) for Sativex, leading to the drug’s approval in Italy, Denmark, Germany, Sweden, the Czech Republic and Austria, in March 2011.
The drug currently has approvals in 29 countries for treating adult patients experiencing moderate to severe spasticity caused by MS, particularly those who haven’t found sufficient relief with other anti-spasticity medications. Buy Nabiximols France
CAUSES & SYMPTOMS OF MS
MS is a chronic, inflammatory demyelinating disease affecting the central nervous system. Some of its common symptoms include vision problems, diplopia, dysarthria, ataxia, cognitive impairment, and sexual dysfunction. Buy Nabiximols USA
Patients may experience Lhermitte’s phenomenon, a brief electrical sensation in the back caused by neck flexion. Spasticity, including muscular spasms and stiffness, is a common symptom of MS, affecting daily activities such as walking and sitting. Other symptoms include limb weakness, tingling, and tight sensations.
Multiple sclerosis may result from autoimmune disorders, infectious agents, environmental factors, or genetic factors. Buy Nabiximols
SATIVEX MECHANISM OF ACTION
CBD is an agonist of the TRPV-1 (vanilloid) receptor, inhibiting adenosine uptake. The human endocannabinoid system contains two types of cannabinoid receptors: CB₁ at nerve terminals in the central nervous system, peripheral tissues and immune cells. Sativex near me
CB₁ receptors are relevant for pain modulation, as they are found on pain pathways in the brain and spinal cord, as well as on peripheral nervous system primary afferent neurons.
CB₂ receptors are primarily present on peripheral and central immune cells, modulating immune function through cytokine release.
THC, the main psychotropic component of cannabis, acts as a partial agonist at both CB₁ and CB₂ receptors. In animal models of MS and spasticity, CB receptor agonists have been shown to improve limb stiffness and motor function.
CBD, which has little activity at cannabinoid receptors, has neuroprotective properties, likely due to its ability to modulate intracellular calcium. CBD’s key pharmacology in MS is likely to inhibit microglial activity and T-cell proliferation. It is unclear whether CBD in Sativex has a facilitative or antagonising effect on THC’s anti-spasticity action.
CLINICAL TRIALS ON NABIXIMOLS
The pivotal Phase III clinical trial served as the basis for the approval of the drug in the UK and Spain.
The trial is a double-blind, randomised, placebo-controlled study of Nabiximols in individuals with MS-related spasticity who had not received a sufficient reduction of their symptoms from other treatments.
The trial’s primary efficacy endpoint was achieved, demonstrating that Nabiximols provides statistically significant benefits. Various additional measurements, including the analysis of responders experiencing at least a 30% improvement; reduction in spasm frequency; decrease in sleep disruption; overall impressions of improvement reported by both patients and physicians; and the disparity between Nabiximols and a placebo; also showed considerable significance of the benefits.
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