It’s difficult to imagine a psychedelic more potent than DMT (dimethyltryptamine) — particularly five-methoxy (5-methoxy-N,N-dimethyltryptamine or O-methyl-bufotenin). Buy 5-MeO-DMT Australia

This compound is a tryptamine-based psychedelic, which means it mimics neurotransmitters like serotonin to exert most of its psychedelic effects. Buy 5-MeO-DMT in Europe

Five-methoxy is naturally-occurring — most predominantly found in a species of toad called Bufo alvarius (AKA the Colorado River Toad or the Sonoran Desert Toad). It’s also common in synthetic form, where it can be smoked, vaped, or insufflated (snorted). Buy 5-MeO-DMT New Zealand

This psychedelic is notoriously fast-acting, but the effects are very short-lived. Buy 5-MeO-DMT

A quick rip of five-methoxy can take you into a timeless hyperspace where users often report chatting with machine elves. While the experience can feel like a lifetime, most users return to reality within 45 minutes. Buy 5-MeO-DMT Italy

Regardless of how short, a trip on five-methoxy can seriously shift your perspective.

Wonderful, terrifying, and sometimes healing, five-methoxy potency is an enigma that can humble and inspire. Buy 5-MeO-DMT Germany

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Active Ingredient	5-MeO-DMT
Level of Risk	Low
Most Common Side Effects	Ego-dissolution, Ineffable
Duration of Effects	Peak 10–30 min, 1-hour total
Legality	Varies, unscheduled in some areas

HOW TO TAKE 5-MeO DMT RESPONSIBLY

1. 🐍 I understand why psychedelics should be treated with respect
2. ⚖️ I’m familiar with the laws surrounding psychedelics in my country & state
3. 🍄 I’m familiar with and confident in the dose I’m taking (smoked “average” dose of synthetic five-methoxy is 8-12 mg). 5-METHOXY-DMT
4. 🧪 I’ve tested a sample of the substance I’m using with a drug-testing kit
5. 💊 I’m not mixing any medications or other substances with 5-MeO-DMT

DIFFERENCE BETWEEN N,N-DMT AND 5-MeO-DMT?

Before going much deeper, let’s be clear — there are several different DMT analogs, each unique from the last. Buy 5-MeO-DMT France

“DMT” usually refers to N,N-DMT, the active psychedelic ingredient in ayahuasca and changa.

Structurally, N,N,DMT and five-methoxy are only differentiated by adding an oxygen molecule to its Indole ring. Buy 5-MeO-DMT UK

While some effects of five-methoxy and N,N,DMT are comparable — i.e., rapid onset and super intense psychedelic experience — the five-methoxy experience transcends the wild, geometric visuals of N,N-DMT. Buy 5-MeO-DMT Canada

The effects of five-methoxy are often conveyed as “oneness,” “non-dual,” or “ineffable.” Ultimately, words can not capture the significance of what five-methoxy can open us up to. Most users will agree that 5-MeO-DMT pushes the user even further between worlds than N,N,DMT. Buy 5-MeO-DMT USA

WHAT IS BUFO ALVARIUS?

Most people know of 5-MeO-DMT through its amphibian source — the Bufo alvarius toad, also known as the Sonoran Desert toad or Colorado River Toad. Buy 5-MeO-DMT Saudi Arabia

These toads exist in a limited range around Northern Mexico and the Southwestern United States. Here, they spend a great deal of time underground, only emerging at night during the summer rains to breed. This period is “toad season,” and an increasing number of people come to collect the toad’s potent secretions. Buy 5-MeO-DMT Wales

The toad’s popularity is leading to overharvesting, endangering the species in its native habitat. Buy 5-MeO-DMT Scotland

A recent report documented “rival groups” fighting over the limited number of specimens. Meanwhile, some sell Colorado river toads online for up to $1,000. There are also concerns about harming the toad when “milking” them of their venom. 5-METHOXY-DMT. Bufo excretes venom as a milky white substance from parotoid glands on its head as a defense mechanism. Buy 5-MeO-DMT England

The venom is then dried for transport and smoking. The venom contains a cocktail of other (potentially) active compounds, such as bufotenin (5-HO-DMT), that are believed to contribute to the effects of 5-MeO-DMT through a concept called the entourage effect [2, 3]. Buy 5-MeO-DMT Switzerland

5-MeO-DMT SNUFFS: Epená, Yopo, & Cohoba

While smoking toad venom is the more popular and perhaps novel method of 5-MeO-DMT consumption, the compound is abundant elsewhere in nature inside many plants and certain Amanita fungi (Amanita citrina and Amanita porphyria) [4]. Buy 5-MeO-DMT Netherlands

Whether bufo’s use is an ancient or modern invention is unknown, but consumption of 5-MeO from plant sources has occurred since ancient times. In fact, snuff use is one of the oldest definitive confirmations of psychoactive substance use. The associated paraphernalia — pipes and snuff trays thousands of years old in South America — offer insight into the practice’s popularity [5]. Buy 5-MeO-DMT Greece

Myths mentioned by Schultes in Plants of the Gods tell of snuffs stolen from the Sun God by his daughter and gifted to humans so they could connect with the spirit world [6]. 5-METHOXY-DMT. These snuffs of the Amazon often contain many different plants working in synergy [7]. The snuffs also go by many different names in various tribes and regions, and not all contain 5-MeO-DMT, such as the tobacco snuff rapé. Buy 5-MeO-DMT Poland

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In Pharmacotheon, Jonathan Ott documents one such snuff known as Epená, sometimes made from various types of virola. It was harvested by scraping a red resin from the inner bark of the tree, then dried or boiled and turned into an amber resin that was ground, sifted, and sometimes mixed with ash. The alkaloid content of the bark of the Virola is mainly 5-MeO-DMT, along with N,N-DMT. Some varieties contain MMT, 6-MeO-DMT, small B-carboline quantities, and others [8]. Buy 5-MeO-DMT Russia

Yopo is a snuff containing beans from the Anadenanthera peregrinhea or Anadenanthera colubrina. Snuffs exist throughout South America under many names and in the Caribbean as Cohoba. Use persists in some areas to this day. While often assumed to be principally 5-MeO-DMT and N,N-DMT, Jonathan Ott has suggested principal compound in yopo is bufotenin (5-HO-DMT.) Reducing psychoactivity to a single compound is difficult with the huge array of plants included in South American snuffs. Buy 5-MeO-DMT Ukraine

ORAL AND SUBLINGUAL 5-MeO-DMT

There’s been some confusion over whether or not 5-MeO-DMT is orally-active or not. Buy 5-MeO-DMT Turkey

Ethnobotanist Richard Evans Schultes first documented oral preparations, which were later investigated by Dennis Mckenna [9]. However, it took some time to unravel the mystery, as Dennis couldn’t replicate the effects witnessed in the Amazon. Pioneering chemist Sasha Shulgin also wrote five-methoxy was inactive orally in TiHKAL [10]. Buy 5-MeO-DMT Belgium

However, in later years, Jonathan Ott documented oral activity with 5-MeO in a capsule of 30 mg. The reported effects were not nearly as potent. Ott further experimented with the addition of harmala alkaloids (a potentially dangerous mix we do not recommend) to achieve greater psychoactive effects. Buy 5-MeO-DMT Sweden

SYNTHETIC 5-MeO-DMT

With the rarity of the toad and Amazonian snuffs, synthetic 5-MeO use has blossomed. It was first synthesized by Japanese chemists Toshio Hoshino and Kenya Shimodaira in 1936 from Anadenanthera peregrinhea seeds. Buy 5-MeO-DMT Austria

Many buy the compound from online research chemical vendors and some chemical manufacturers. Buy 5-MeO-DMT Norway

Synthetic 5-MeO-DMT comes in either a white to yellow or orange crystalline powder. Pure 5-MeO-DMT

5-MeO-DMT DOSE

The effective dose of 5-MeO-DMT depends on the delivery method — smoked, vaped, snorted, swallowed, injected, or taken rectally. Natural 5-MeO-DMT

The form also matters — toad venom, synthetic, snuff, or oral preparation.

Administration of snuffs sourced from the Amazon should be done by a trained practitioner, as dosage can vary depending on the specific plants and preparation method used. Buy 5-MeO-DMT Croatia

In Tryptamine Palace, James Oroc notes that finding an optimal dose when smoking is best adjusted in 2 mg increments. He also explains that finding your “minimum effective dose” helps you actually remember the transcendental experience. This is because it is easy to smoke too much, get stuck in a “white hole,” and have no recollection of what happened [11]. Buy 5-MeO-DMT Denmark

1. BUFO TOAD VENOM DOSAGE

The standard dose range for raw Bufo alvarius toad venom is between 10 and 60 mg, smoked or vaped.

Bufo toad venom alkaloid concentration varies. Alexander Shulgin reported in TiHKAL that the venom could contain up to 15% 5-MeO-DMT. Buy 5-MeO-DMT Romania

Other sources mention a range of 10-30%. In short, potency is highly variable, and individual responses to bufo will vary greatly. Always start small, work your way up, and find an experienced practitioner when working with toad venom. Buy 5-MeO-DMT Ireland

2. SYNTHETIC 5-MeO-DMT DOSE

Synthetic 5-MeO is often smoked but is also sometimes snorted, boofed, and taken orally or sublingually. Smoking will come on fast and end quickly. Snorting, plugging, and oral routes have a gentler, slower come-up and will last longer. Buy 5-MeO-DMT Finland

When deciding which access route to take, consider if the substance is HCl or freebase. Most favor HCl for snorting and freebase for smoking. Snorting will burn (freebase a lot), and online reports suggest rectal might too. Both methods are known to cause nausea. Buy 5-MeO-DMT Luxembourg

Dose Level	Smoked/Vaped	Snorted
Threshold	1-5 mg	3-5 mg
Low Dose	5-7 mg	5-10 mg
Standard Dose	8-12 mg	8-15 mg
High Dose	13-20 mg	10-25 mg

3. OTHER METHODS OF TAKING SYNTHETIC 5-MeO-DMT

While far less common than the other methods outlined above, some prefer to take 5-MeO sublingually (under the tongue), orally (swallowed as a capsule), or rectally (AKA “boofing”). Buy 5-MeO-DMT Czechia

Sublingual	10 mg
Oral	20-30 mg
Rectal	20-30 mg

WHAT DOES 5-MeO DMT FEEL LIKE?

The effects of 5-MeO-DMT depend on the method of consumption and whether or not you “breakthrough.” Buy 5-MeO-DMT Albania

Threshold doses of 5-MeO-DMT bring a brightness to the world, what Jonathan Ott calls “a magical varnish” over reality. Fractal geometry can be entertaining. Some people experience a significant “body load,” a sensation of heaviness or amplified gravity. Alexander Shugin described this as “blood turning into cement.” Buy 5-MeO-DMT Iceland

At higher doses, one leaves the body and everyday reality behind. A common theme is merging with white light, the universe, God, or love. Some people encounter entities, spirits, and ancestors. Many people will hear a sound associated with high-dose DMT (some consider it “om,” the sound of creation). Perception of time may change or cease to exist altogether. All this can carry great emotional significance and release. Buy 5-MeO-DMT Malta

5-MeO-DMT can be incredibly beautiful but is extremely intense. Being able to “let go” is helpful but can be challenging in the face of such a potent experience. The sense of losing control can be very humbling. Deep breaths and surrendering make the experience smoother, along with compassion for yourself for trying one of the most powerful psychedelics known. Buy 5-MeO-DMT Hungary

Skilled facilitators can also help you prep and integrate for 5-MeO.

Common Features of 5-MeO-DMT include:

• Fractals
• White light
• “The Sound”
• Spirits, God, Ancestors, Love
• Oneness, ego-dissolution, out-of-body
• Overwhelm, losing control, “too much”
• Timelessness

HOW LONG DOES 5-MEO-DMT LAST?

5-MeO-DMT is notoriously short-acting. This has led many to refer to this drug as a “business trip.” Most intake methods don’t last longer than about 45 minutes. However, there’s some nuance here depending on how much you took and how you took it. Buy 5-MeO-DMT Cyprus

1. SMOKING OR VAPING 5-MeO DMT

Smoked or vaporized, 5-MeO-DMT takes effect within seconds. Buy 5-MeO-DMT Bulgaria

At high enough doses, the sense of disconnect from one’s body lasts 5-20 minutes.

After this peak, the effects rapidly disappear, and within 45 minutes to an hour, full sobriety settles in. Buy 5-MeO-DMT Slovenia

The body metabolizes 5-MeO-DMT very rapidly, so you will never get stuck in 5-MeO-DMT mode.

While the effects don’t last long, it’s best to give yourself some time to rest and process 5-MeO-DMT, as the experience can be a lot to take in. Buy 5-MeO-DMT Estonia

2. SNORTING OR SWALLOWING 5-MeO DMT

When snorted, the effects begin acting within minutes, peaking around 10-20 minutes. After 45 minutes, the effects lessen, and the entire experience lasts about an hour for most people. Buy 5-MeO-DMT Serbia

Depending on the preparation, particularly with various snuffs, some people experience lingering effects for up to three hours later. Buy 5-MeO-DMT Serbia

Oral consumption is similar but with a 30-minute delay. The effects kick in about 40–50 minutes after taking it, remain active for about 20-30 minutes, and taper off over the next hour. Some lingering effects may remain for several hours. Buy 5-MeO-DMT Slovakia

IS 5-MeO-DMT THE STRONGEST PSYCHEDELICS?

5-MeO-DMT is 4-5 times stronger than N-N,DMT — according to Jonathan Ott in Pharmacotheon. Buy 5-MeO-DMT Montenegro

It’s also stronger than most other psychedelics. Even high doses of psilocybin (the active ingredient in magic mushrooms) are about 10% as strong as a standard dose of 5-MeO-DMT. Mescaline (the active ingredient in Peyote and San Pedro Cacti) is about the same. Buy 5-MeO-DMT Lithuania

Even very powerful psychedelics like salvinorin A (the active ingredient in Salvia divinorum) are notably milder in the depth of experience. Buy 5-MeO-DMT Liechtenstein

Technically speaking, the lysergamide family (LSD, AL-LAD, PRO-LAD, LSZ, ETH-LAD, 1P-LSD, and others) are stronger than 5-MeO-DMT, but only when you compare the dose. The effects of these compounds are far less intense than 5-MeO-DMT. Buy 5-MeO-DMT Bosnia and Herzegovina

The standard oral dose range for lysergamides like LSD is between 80 and 120 mcg. Compare this to around 20 or 30 mg for 5-MeO-DMT. This makes LSD significantly stronger, but even in very high doses, LSD doesn’t completely blast apart our perceptions of reality and time the way 5-MeO-DMT can. Buy 5-MeO-DMT Andorra

IS 5-MeO-DMT SAFE?

While you’re unlikely to die from an overdose on 5-MeO-DMT, it can still be dangerous if misused.

The usual psychedelic cautionary notes apply — people with physical health problems like heart conditions might be at risk. Those with mental health concerns like schizophrenia, bipolar, or other diagnoses should not use 5-MeO-DMT. Consult with a trusted professional if you’re uncertain. Buy 5-MeO-DMT Belarus

SIDE EFFECTS OF 5-MeO-DMT

Side effects like seizures, self-harm, violent physical releases, and psychosis have occurred in some people without warning. There are some reports of people dying from choking on vomit after taking 5-MeO-DMT by themselves. Buy 5-MeO-DMT Latvia

ADDICTION AND ABUSE

Addiction is also rare but not unheard of — especially with the advent of DMT vape pens, many users find themselves puffing on DMT compulsively. This can significantly increase the risk of mental health disorders like psychosis or hallucinogen-persisting perception disorder (HPPD). Buy 5-MeO-DMT Monaco

THE DANGERS OF TRIPPING ALONE ON 5-MeO-DMT

Using 5-MeO-DMT without a tripsitter is not recommended. During the experience, a loss of bodily control is common. Having someone nearby to protect you from harm while under the effects is a necessity. This person should be a trained facilitator who knows CPR. Buy 5-MeO-DMT Vatican City

PRESCRIPTION DRUGS INTERACTION

Do not mix 5-MeO-DMT with prescription drugs, including SSRIs (selective serotonin reuptake inhibitors), MAOIs (monoamine oxidase inhibitors), or other antidepressants or antipsychotics. Buy 5-MeO-DMT Moldova

Anyone mixing 5-MeO-DMT with harmala alkaloids should be extremely careful, as these can also cause potentially lethal consequences. Buy 5-MeO-DMT San Marino

5-MeO-DMT OVERDOSE

While rare, an overdose on 5-MeO-DMT is possible, and there have been reports of this happening in the past. Shulgin includes a harrowing account in THiKAL of needing to resuscitate someone who stopped breathing after taking too much. There are also concerns about mixing 5-MeO-DMT with ayahuasca, with at least one death reported in the literature [12]. Buy 5-MeO-DMT North Macedonia

LONG TERM SIDE EFFECTS

Long-term side effects from 5-MeO-DMT are rare and can normally be avoided through intentional use and adequate integration following the experience. Buy 5-MeO-DMT Kosovo

One of the most common persisting side effects is anxiety or a vague sense that “something” is wrong. Buy 5-MeO-DMT Faroe Island

Difficulty sleeping or “grounding” is also not uncommon after taking 5-MeO. Some practitioners encourage eating heavy foods for a few weeks after the experience to offset this effect. Buy 5-MeO-DMT Isle of man

There is also the potential for flashbacks, known as “reactivations.” This isn’t a rumor; it’s well documented in research, but the exact cause is unknown [13]. Some subjects report quick flashes, while others report a full-blown experience. Reactivations can last anywhere from a few seconds to a week. Buy 5-MeO-DMT Gibraltar

PURE 5-MeO DMT

The Erlich and Hoffman regent tests are the best way to test 5-MeO-DMT samples for purity.

It’s always wise to test a sample of your drugs BEFORE you take them. But remember that testing doesn’t guarantee safety or purity and is best used to rule out certain dangerous compounds. Buy 5-MeO-DMT Aland Islands

The Erlich test cannot confirm the presence of 5-MeO-DMT but is helpful to distinguish if you do, in fact, have an indole (and not something dangerous like an N-Bombs). Buy 5-MeO-DMT Svalbard and Jan Mayen

A successful test will turn a purplish color; view the video here.

To further distinguish between tryptamines, a Hoffman reagent test works well. For example, if you are unsure if you have N,N-DMT, or 5-MeO-DMT. For 5-MeO-DMT, the Hoffman test will turn green. If it is N,N,DMT, a yellowish color will appear instead. Buy 5-MeO-DMT Jersey

IS 5-MeO-DMT LEGAL?

The legality of 5-MeO-DMT varies. It was not banned alongside other psychedelics in the 70s as it was not as popular then. However, since its reputation has grown, 5-MeO-DMT has been a Schedule 1 substance in the United States since 2011. Dried bufo alvarius venom

Other countries have yet to ban this substance — most notably Canada, where 5-MeO-DMT is readily sold online and in some dispensaries. Where can i find real 5-meo-dmt

HOW DOES 5-MeO-DMT WORK?

5-MeO-DMT is a serotonergic psychedelic. This means it primarily binds to the serotonin receptors — most notably the 5HT1A, 5HT2A, and 5HT2C receptors. Buy 5-MeO-DMT Jamaica

5-MeO-DMT has a methoxy group attached to its primary ring structure (known as an indole ring). This methoxy group may create a higher receptor binding affinity than its DMT relatives. This is why it works so rapidly and powerfully compared to other forms of DMT. Buy 5-MeO-DMT UAE

Some studies also show interesting and promising data regarding the use of 5-MeO DMT for various mental health conditions, including [14]:

• Anxiety
• Depression
• Immunomodulation
• Inflammation
• Life satisfaction
• Mindfulness
• Neuroendocrine effects
• Obsessive-compulsive disorder
• PTSD
• Stress
• Substance use disorder

5-MeO-DMT FAQS

If we still haven’t answered your question, email us at contact@eatpsilocybin.com

1. LICKING THE BUFO ALVARIUS TOAD

You can lick toads, but don’t expect to get high, only sick. There are hundreds of species of Bufo toads, but we only know that Alavrius contains enough alkaloids for a psychedelic experience. While it’s possible to eat toad venom for psychoactive effects, keep in mind that toads secrete venom as a defense mechanism — it’s supposed to make you feel uncomfortable. There are reports of animals and children having fatal responses to bufo venom. Bufo alvarius venom

2. WHERE CAN I FIND 5-MeO-DMT RETREAT?

While unscheduled in countries like Canada or parts of Europe, it may be difficult to find retreats openly offering 5-MeO-DMT. Mexico and some parts of South America have fairly open use of 5-MeO-DMT with a growing number of retreat options. Some practitioners perform individual and group 5-MeO-DMT ceremonies. Be sure to vet any practitioner thoroughly. Order 5-MeO-DMT

3. WHERE CAN I BUY 5-MeO-DMT ONLINE?

Depending on your location, it is possible to buy 5-MeO-DMT in areas where it is not a scheduled substance. There are established options in Canada and some parts of Europe, but be aware that various jurisdictions will treat unscheduled drugs differently. Unscheduled is more of a “grey area” than being legal or decriminalized, so research carefully. Where can i purchase 5-MeO-DMT

4. DOES 5-MeO-DMT CAUSE FLASHBACKS

Yes, 5-MeO-DMT does sometimes have persisting effects called reactivations. While this is not technically considered the same as hallucination persisting perception disorder (HPPD), which is a serious medical condition, a significant number of people have reported having brief glimpses or very strong feelings that continued for some time after 5-MeO-DMT. Exactly why this happens is unclear and may relate to too-high or repeated uses in one sitting. Buy 5-MeO-DMT near me

5. WHERE CAN I FIND MORE 5-MeO-DMT RESOURCES?

With the popularity of psychedelics on the rise, 5-MeO-DMT resources and organizations have been showing up. Some helpful educational platforms and help to find facilitators and integration practitioners include: 5-MeO-DMT for sale

• Five — An education platform and integration resource.
• The Conclave — Providing quality information about best practices, ethics, and integration
• 5 Hive — A 5-MeO-DMT-focused discussion forum.
  Hello Psychonauts – An online platform that provides safe access to premium quality psychedelic substance.

  AN OVERVIEW OF 5-MeO-DMT

  5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT), as well as one species of toad. 5-MeO-DMT can also be synthetically produced. Where can i buy 5-MeO-DMT in Australia

  In Central and South America, 5-MeO-DMT is most often sourced from Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff. Where can i buy 5-MeO-DMT in Europe

  It’s also found in the milky white venom of the Sonoran Desert Toad (Bufo alvarius/Incilius alvarius; aka the Colorado River Toad ), which is native to the southwestern United States and northwestern Mexico. Venom harvesting has put pressure on the population of this ecologically sensitive species. It’s currently listed as imperiled or locally instinct in several states in the US. Seeking out alternatives sources of 5-MeO DMT, such as synthetic or plant-derived versions, is strongly recommended. Where can i buy 5-MeO-DMT in New Zealand

  WHERE CAN I BUY 5-MeO-DMT ONLINE

  In keeping with its ceremonial use among indigenous Amazonians, 5-MeO-DMT shows great promise in the treatment of certain medical conditions. In fact, a single inhalation of the substance has been shown to greatly improve general well-being and mindfulness as well as reduce the symptoms of psychological disorders. 5-Meo-DMT source

  While research into 5-MeO-DMT is limited, a few studies have supported the anecdotal evidence. In a recent preliminary study, 42 participants who took 5-MeO-DMT reported high levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks, when a follow-up assessment was completed.

  These results support the findings of a survey of 362 people who had taken 5-MeO-DMT. After using the psychedelic, 80% of respondents reported improvements in anxiety and depression.5-MeO-DMT has seen a meteoric rise in popularity over the past few years as anecdotal reports of its potential as a healing agent have come to light. This has incentivized some bad practices among guides and other practictioners, including everything from overharvesting and the ecological strain on Sonoran Desert toad mentioned above, as well as sexual abuse and even unintended deaths in several documented cases.

  5-MeO-DMT EXPERIENCE

  5-MeO-DMT is one of the most potent psychedelics you can consume, and the experience can be intense and powerful—in both positive and negative ways. Though everyone will undergo a unique and individual experience, there are some general things you can expect.

  WHAT TO EXPECT WHEN TAKING 5-MeO-DMT

  Vaporizing or smoking 5-MeO-DMT powder is the most common route of administration. The effects are usually felt within the first 30 seconds after consumption, peaking from 1-15 minutes and lasting for up to half an hour. When taking synthetic 5-MeO-DMT, a threshold dose is around 1-2 mg, while a standard full dose is 8-12 mg. When naturally derived, the threshold dose is 5-10 mg and a standard full dose is 30-60 mg. 5-MeO-DMT retreat near me

  When swallowed, doses are generally higher, but also show generally unreliable results.^[1] Other less common routes of administration include sublingual (under the tongue) and injection.^[2]

  The effects of 5-MeO-DMT come on strong, often with a loss of physical coordination and control. Users experience bright colors, moving environments, or recursive patterns, and perhaps even “environmental orbism” at higher doses. However, visual effects are limited. Unlike DMT, 5-MeO-DMT isn’t known for its visionary properties. The experience is more often described as a “perspective shift” characterized by physical, emotional, and conceptual effects. 5-MeO-DMT retreat cost

  One of the most common features of the 5-MeO-DMT experience is the enhancement of tactile awareness, which can reach the point of sensory overload. The body may also feel heavier. Intense emotions are typical, ranging from extreme fear to euphoria. During the onset, anxiety or excitement are often felt. It’s also common to experience an overwhelming sense of oneness with the universe, or a sense of being outside of time and space while simultaneously experiencing the totality of both. Ego death is also typical of the 5-MeO-DMT experience. Other effects include auditory hallucinations, time distortion, nausea, and memory loss.^{[2][3][4][5][6]}

   

  PHARMACOLOGY OF 5-MeO-DMT

  Like the other tryptamines, 5-MeO-DMT has the same basic structure as DMT, but has a methoxy group in the R5 position. It works primarily as a serotonin (5-HT) receptor agonist, with a particular binding affinity to the 5-HT1A receptor subtype.^[7] It also binds to 5-HT2A and trace amine receptors, possibly mediating hallucinogenic effects via the latter.^[8] Reuptake inhibition of neurotransmitters such as noradrenaline and dopamine are also thought to be involved in 5-MeO-DMT’s function. 5-MeO-DMT extraction

  TOXICITY OF 5-MeO-DMT

  There is some evidence that indolealkylamines, including 5-MeO-DMT, cause serotonin syndrome when overdosed or combined.^[9] Of particular concern are possible interactions with monoamine oxidase inhibitors (MAOIs) such as harmaline or harmine.^[10][11] These are sometimes combined with the drug to enhance its effect, but can dangerously increase exposure to both 5-MeO-DMT and its active metabolite bufotenine.^[12]

  Some other safety concerns have been flagged by animal studies. In rats, 5-MeO-DMT was found to induce hypothermia at low doses (0.5-1 mg/kg) and hyperthermia at high doses (3-10 mg/kg). In sheep, grazing on the 5-MeO-DMT-containing Phalaris tuberose/aquatica (or bulbous canary-grass) caused fatal tachycardia and respiratory failure.^[7] Although more likely due to other toxins in the plant^[13], this severe reaction underscores the need for caution when approaching 5-MeO-DMT’s many and varied natural sources. Where to get 5-MeO-DMT

  DOSING 5-MeO-DMT

  5-MeO-DMT doses are different depending on whether the substance is synthetic and naturally derived.

  SYNTHETIC 5-MeO-DMT

  Small: 3-6 mg
  Medium: 6-10 mg
  Large: 11-15+ mg

  BUFO TOAD VENOM

  Small: 10-20 mg
  Medium: 20-40 mg
  Large: 40-60+ mg

  BENEFITS AND RISK

  POTENTIAL BENEFITS

  5-MeO-DMT has been used as a healing agent by South American shamans for thousands of years, partially due to its ability to occasion mystical-type experiences. While research into the drug is still limited, recent studies are backing up these ancient claims. 5-MeO-DMT visuals

  In a survey of 362 adults, 80% of respondents reported improvements in anxiety and depression after using 5-MeO-DMT, as well as an increase in well-being and life satisfaction. More than that, improvements were directly related to the intensity of the mystical effects felt during the experience. Respondents that had intense mystical experiences also reported higher rates of the experience’s personal meaning and spiritual significance. 5-MeO-DMT toad

  The benefits of 5-MeO-DMT have also proven to be enduring—in a recent preliminary study,^[76] 42 participants who took 5-MeO-DMT reported an increase in levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks after the initial experience when a follow-up assessment was completed. 5-MeO-DMT retreat in Europe

  One of the unique aspects of 5-MeO-DMT is the short duration of the experience compared to more common psychedelics, such as LSD and psilocybin. While research has shown that psychedelic-assisted psychotherapy can help people with a variety of psychological disorders, these sessions often require a 7 to 8-hour session. Because 5-MeO-DMT is short-acting and lasts just 30-90 minutes, it shows promise as an accompaniment to therapy sessions, which are typically 60 to 90 minutes. 5-MeO-DMT retreat Australia

  Risks

  A recent study from The Journal of Psychopharmacology found that 5-MeO-DMT is safe to use and has a low risk of health consequences. 5-MeO-DMT retreat UK

  However, there are some things to be aware of before diving into an experience. 5-MeO-DMT should not be taken with MAOIs, including some antidepressants. Combining them may cause severe hypertensive symptoms (elevated blood pressure, heart rate, and temperature), seizures, long-term kidney damage, serotonin syndrome, and even death.^[14]

  Because of the somewhat unpredictable nature of 5-MeO-DMT, a sitter is definitely recommended. Short-term unconsciousness, respiratory depression, and delusional interactions with the environment are some of the things to watch out for.^[15] At the very least, it should be taken in a comfortable seated or lying position to avoid falling over. 5-MeO-DMT retreat Canada

  Those new to 5-MeO-DMT should start out with a low dose, weighed on a scale accurate to 0.002 g (2 mg). Since people tend to react differently to the same doses (and it’s not entirely clear why) caution is advised, even if you have prior experience of tryptamines.

  As with any psychedelic, follow the 6Ss of psychedelic use to minimize the risks of a bad experience. 5-MeO-DMT retreat New Zealand

  THERAPEUTIC USE OF 5-MeO-DMT

  While clinic research into 5-MeO-DMT’s therapeutic use is limited, the psychedelic has been shown to alleviate depression, anxiety, PTSD, and addiction.^[16][17] It’s also sometimes used alongside ibogaine treatment to help patients integrate their experience.^[18]

  In the past few years, however, interest in 5-MeO-DMT has grown, along with research. In one study, researchers gave 5-MeO-DMT to mice and found a major downregulation in mGluR5, a receptor involved in the reward mechanism of drug abuse. Not only are mice without the mGluR5 gene less likely to self-administer cocaine and ethanol, they also show less severe symptoms of nicotine withdrawal. Furthermore, cells treated with 5-MeO-DMT showed an upregulation of integrins. Antidepressant medications create a similar response, suggesting that 5-MeO-DMT could have antidepressant properties.^[19]

  As previously mentioned, in two recent surveys totaling more than 400 people, the vast majority reported improvements in anxiety and depression after using 5-MeO-DMT, as well as an increase in well-being and life satisfaction. For some, the experience also helped them recover for PTSD or addiction. 5-MeO-DMT retreat Florida

  WHERE CAN I GET 5-MeO DMT IN THE UNITED STATES

  The John Hopkins Center for Psychedelic Research is beginning to study the effects of 5-MeO-DMT, with researcher Alan Davis believing the drug could be effective at treating mental illness due to neurological changes in users’ brains caused by the substance as well as insights gained through the psychedelic experience. 5-MeO-DMT retreat California

  Dr. Joseph Barsuglia, Clinical Research Director at Mexico’s Crossroads Ibogaine Treatment Center, is also researching 5-MeO-DMT as a potential treatment for addiction. He believes that using 5-MeO-DMT in partnership with the psychedelic ibogaine could prove to be a powerful combination for eradicating issues of substance abuse. “People are talking about melting into God, being united with the universe, clearing longstanding trauma and pain that was stored in their bodies,” he said. “We’re finding that the combination of [5-MeO-DMT and ibogaine] is like… 1+1=5. It’s just exponential.”5-MeO-DMT retreat Texas

  Additionally, 5-MeO-DMT appears to have a placebo analgesic effect comparable to hypnosis.^[20][21][22] Like the other classical psychedelics, it may be useful in the treatment of acute and chronic inflammatory conditions^[23][24], including some cancers.^[25][26]

  More indirectly, 5-MeO-DMT is also helping researchers better understand the neurobiological basis of schizophrenic hallucinations—ultimately paving the way for more effective antipsychotic drugs.^[27]

  PERSONAL GROWTH AND 5-MeO-DMT

  While 5-MeO-DMT shows promise as a therapeutic tool, the drug has been used for centuries as a tool for personal and spiritual growth. In fact, a recent survey from Davis and Barsuglia found that most users of 5-MeO-DMT used the drug for spiritual exploration and reported intense mystical-type experiences, including ego death. 5-MeO-DMT retreat Switzerland

  This experience is often described in positive terms—even if it was terrifying at the time. Many see it as a process of death and rebirth followed by lasting self-improvements, including mental clarity, increased motivation, enhanced awareness, joy in living, and a sense of inner peace. Some have also had enlightenment experiences, characterized by a sense of inseparability from the universe or of being “all that exists.”^[28][29][30] Often, these experiences come in waves or reactivations over the following days or weeks. 5-MeO-DMT retreat

  Being forced to let go of the ego is precisely what draws many people to 5-MeO-DMT. The dissolution experience can impart an understanding and acceptance of mortality that helps people overcome the fear of death.^[16] It can also heal past trauma, negative behaviors, and habitual negative thought patterns. 5-MeO-DMT retreat Germany

  One group of 5-MeO-DMT ‘practitioners’ have also reported that there are a number of specific integration and grounding techniques to increase the potential for growth. These include acupuncture, massage, physical exercise, certain foods, and even just talking to others. Interestingly, they advise against meditation because it could end up prolonging the grounding/integration period by triggering additional reactivations. 5-MeO-DMT retreat

   

  LEGALITY OF 5-MeO-DMT

  5-MeO-DMT legality in USA

  5-MeO-DMT is a Schedule I controlled substance in the US, making it illegal to manufacture, distribute, possess, or buy. 5-MeO-DMT-containing plants, however, are generally not controlled, particularly in Oakland, CA, all “entheogenic plants” were decriminalized in 2019. This allows adults aged 21 years and older to use them either medicinally (in accordance with the resolution’s official intent) or for any other reason without fear of criminal punishment. It also specifically decriminalizes (or rather deprioritizes for law enforcement) their cultivation and distribution.^[31][32]

  5-MeO-DMT legality in Canada

  Some people choose to buy 5-MeO-DMT in Canada, where the substance is not controlled.^[33] However, it should go without saying that a 5-MeO-DMT supplier in Canada cannot legally ship the substance to a country where it remains illegal.

  5-MeO-DMT legality in Mexico

  The legal status of 5-MeO-DMT in Mexico is similar to Canada. However, it has a less clandestine feel south of the border; 5-MeO-DMT retreats are actually quite common in Mexico.

  It’s so critical to diligently vet facilitators and be careful who you choose to sit with. For more information on how to select a 5-MeO DMT retreat, we recommend visiting our Psychedelic Directory.

  5-MeO-DMT legality elsewhere

  Laws prohibit the use of 5-MeO-DMT in the UK, Australia, New Zealand, and many European countries. In Denmark, it’s permitted for use in research.^[34]

   

  Accessing quality psychedelics can seem challenging, especially when you’re unsure how to navigate the legal complexity or choose a reputable vendor. That’s why we compiled step-by-step instructions and resources into the Ultimate Guide to Sourcing Psychedelic Medicines.

  ETHICAL CONSIDERATION

  5-MeO DMT and the Sustainability of the Sonoran Desert Toad

  Though there are several natural and synthetic sources of 5-meo-dmt, the use of “toad medicine” has become venerated, increasing its demand in Mexico, the United States, and in some countries in Europe and South America. This has put a strain on the Sonoran Desert Toad (Bufo alvarius) population, whose habitat is relatively small, spanning southeastern California, southern Arizona, southern New Mexico, and northwestern Mexico.

  In the United States, there are ongoing efforts to add the Sonoran Desert toad to the endangered species list.^[75] And while it’s not currently listed as a protected species at the federal level, it is considered imperiled in New Mexico and possibly locally extinct in southern California.

  Though the International Union for Conservation of Nature (IUCN) does not classify the toad as an endangered species, the classification dates back to 2004, which doesn’t reflect the recent surge in interest in the toad’s therapeutic and psychedelic potential. In addition to endangering the population, this is also causing the toad to become a victim of black market trafficking as well as inhumane breeding and “milking” practices in captivity.

  The destruction of the toad population can be avoided by using synthetic five-methoxy instead of vapor from the toad. Many people believe toad medicine is superior because of its “purity”, but there is no evidence that five-methoxy derived from toads produces a better/different experience or outcome than synthetic 5-MeO-DMT.

  CULTURAL ETHICS

  Cultural considerations also need to be taken into account. A group of eight indigenous cultures originally from the Sonoran Desert have started promoting the use of the substance as an effort to revive their cultural identity. There is some debate as whether or not toad medicine was used in these cultural practices prior to Ken Nelson’s discovery of the toad’s psychoactive effects.

  In either case, the use five-methoxy into the indigenous cultures of the US has also brought it into the reclamation of ancestral medicine in Mexico.

  While these groups traditionally use peyote, mushrooms, ayahuasca, and iboga in their ceremonies, the Bufo alvarius toad is now joining (or rejoining) the list.

  This brings up the question of cultural appropriation. Toad medicine is being used in locations and contexts that are very different from the indigenous cultures in which it originated.

  Small scale, local use of the toad-derived 5-MeO DMT in indigenous practices is much more likely to be sustainable and arguably more ethical, especially when considering many of these populations don’t have access to alternatives. But beyond local use, where plant-based and/or synthetic alternatives are more easily accessible, it’s difficult to argue for harvesting the toad-derived compound at scale.

  ETHICS VIOLATION AMONG GUIDES

  Psychonauts, neohealers, therapists, and urban shamans alike are becoming 5-MeO-DMT facilitators, and retreats offering 5-MeO-DMT in ceremonial settings for profit are popping up in Mexico and South America.

  While this has caused friction with practitioners from indigenous cultures, it’s also created a market for charlatans taking advantage of people under the influence of 5-MeO-DMT and not in control of their bodies. Two such practitioners—Gerardo Sandoval and Octavio Rettig—have been accused of sexual abuse, psychological manipulation, intentional overdosing, physical violence, hospitalizations, and, in Rettig’s case, at least four deaths.

  This highlights the need to be diligent in vetting facilitators and to be careful who you choose to sit with. For more information on how to select a 5-MeO DMT retreat, we recommend visiting our psychedelic directory and checking out this informative guide.

   

  HISTORY OF 5-MeO-DMT

  Traditional use of 5-MeO-DMT in the Americas goes back hundreds—maybe even thousands—of years. Ancient snuffing paraphernalia and traces of the compound found in northern Chile date the practice to at least the 8th century.^[35] The use of 5-MeO-DMT-containing snuff was first recorded in 1496 by Friar Ramón Pané. Reporting to Christopher Columbus on the Taíno people of Hispaniola, Pané observed inhalation of cohoba snuff through reeds. It was often to help sick people purge, as well as a medium to obtain medical diagnoses from spirits.^[36]

  In 1737, Joseph Gumilla observed a similar practice, with yupa (or yopo), among the Otomac of southern Venezuela.^[37] Some time later, Alexander von Humboldt described how the snuff was made. First, the seeds of the Acacia niopo (Adenanthera peregrina) were left to blacken, then mashed into a paste with cassava flour and lime from snail shells. This mixture was dried over a fire and pulverized for use, then inhaled through a Y-shaped bone tube, such as a plover leg, with the forked ends straddling the septum.^[38] Another account from Richard Spruce in the mid-1800s described the use of tubes between two people—one to blow the snuff into the nostrils of the other.^[39] Spruce also collected specimens of the Adenanthera peregrina for identification.

  WHERE CAN I GET 5-MeO DMT IN EUROPE

  In 1936, 5-MeO-DMT was synthesized by the chemists Toshio Hoshino and Kenya Shimodaira.^[40] But it wasn’t until 1959 that it was finally identified as the major psychoactive component of yopo/cohoba.^[41] It was also found in the venom of the Colorado River Toad (Bufo alvarius/Incilius alvarius or Sonoran Desert Toad), sometimes at levels of up to 15% by volume.^[42]

  From the early 1970s, 5-MeO-DMT could be legally ordered in the US and other countries via mail order from the Church of the Tree of Life^[43] and the Church of the Toad of Light.^[44] Since scales accurate to the microgram weren’t widely available, it was typically added to parsley or cannabis to help with dosing.^{[45] 5-METHOXY-DMT}

  Recreational use steadily increased over the ensuing decades while remaining underground. In the 1990s, ethnobotanist Jonathan Ott and others popularized and developed 5-MeO-DMT for sale on the internet. In 2001, the research chemical vendor Mark Niemoller was arrested under the Controlled Substances Analogue Act of 1986. He was released on house arrest after agreeing to stop selling 5-MeO-DMT and a number of other substances.^[46] In July 2004, “Operation Web Tryp” saw the DEA shut down five more 5-MeO-DMT and research chemical vendors, prompting numerous others to stop trading voluntarily. In January 2011, 5-MeO-DMT was declared a Schedule I drug in the United States.

  CURRENT USE OF 5-MeO-DMT

  5-MeO-DMT is often conflated with other tryptamines or “novel psychoactive substances” in major drug surveys, so it’s difficult to gauge how prevalent its use is. However, it’s possible to get a general feel for its popularity over time by looking at Google search statistics. Between 2004 (the year of “Operation Web Tryp”) and 2007, searches for 5-MeO-DMT fell dramatically and have remained at a steady low ever since.

  Myths

  “5-MeO-DMT is a form of DMT”

  This myth is based on a common, and potentially very dangerous, misunderstanding of pharmacology. It’s no more a form of DMT than psilocybin is. Although the two substances are chemically related, the effects of 5-MeO-DMT and DMT are substantially different, as are their safety profiles. 5-MeO-DMT, for example, has a much lower toxicity threshold than DMT, so conflating the two could be dangerous.

  “Licking toads is an easy way to get high.”

  Alexander Shulgin attributed this myth (or rather, very bad idea) to sensationalism in the media.^[48] Licking the Colorado River Toad has never been a common method for obtaining 5-MeO-DMT, for the simple reason that it’s deadly. Other chemicals in raw toad secretions are known to be cardiotoxic, which means they’ll disrupt the functioning of the heart. Numerous humans have died after licking toads and one child who was hospitalized with seizures from the venom took a week to recover.^[49] Given that just this one, geographically isolated species is known to be psychoactive, there’s also the danger of licking the wrong toad entirely, which can cause death or permanent paralysis. 5-METHOXY-DMT

  FAQS ABOUT 5-MeO-DMT

  Where can I find legal 5-MeO-DMT retreats and experiences?

  Third Wave has created its own psychedelic provider directory for you to find curated, legal 5-MeO-DMT retreats. All retreats listed have either been verified or rigorously vetted by the Third Wave team, so you can feel confident knowing that these options are worth considering in this vulnerable and transformative experience. 5-METHOXY-DMT

  Can it be detected in a drug test?

  5-MeO-DMT isn’t detected in any standard or extended drug tests, nor are there specialized tests to look for it. Also, since it’s unlike other drugs tested for, it shouldn’t trigger a false positive. 5-METHOXY-DMT

  Where can I buy 5-MeO-DMT online in Europe?

  You can usually find 5-MeO-DMT for sale from vendors in Netherlands, Canada, Mexico, and other countries where it isn’t controlled. If you don’t live in one of these countries, however, it’s still illegal to buy 5-MeO-DMT online from a vendor in Europe (for example) and import it. 5-METHOXY-DMT

  Can I test my 5-MeO-DMT to see if it’s safe to take?

  Testing your 5-MeO-DMT is always good practice even when you trust your supplier. Reagent test kits from Bunk Police can identify hundreds of adulterants and substitutes—offering peace of mind and potentially saving your life. 5-METHOXY-DMT

  The Hofmann and Mecke reagents, for example, can help identify real 5-MeO-DMT. Simply place a tiny amount of 5-MeO-DMT into a sterile test tube or onto a sterile white ceramic surface and add a few drops of the reagent. Then check the color change (or lack thereof) against the supplied spectrum booklet. 5-METHOXY-DMT

  Can 5-MeO-DMT cause psychological trauma?

  Most people find the 5-MeO-DMT experience overwhelming. Consensus reality, the physical environment, body, and self tend to fall away and behavior can become irrational. While long-term psychosis seems improbable, it may take some time to fully recover from the 5-MeO-DMT experience.

  After higher doses, some users have reported persistent psychological difficulties, including paranoia and the subtle (but controllable) resurfacing of effects, that can last for several weeks. 5-METHOXY-DMT

  “White-outs” and memory suppression are also common during the 5-MeO-DMT trip itself, negatively affecting users’ ability to form memories of the altered state.^{[2][4] 5-METHOXY-DMT}

  Are there risks?

  Taken in the presence of a sitter with no other drugs or contraindicated medications (like MAOI antidepressants), 5-MeO-DMT appears to be relatively safe. That said, persistent anxiety has been reported after just one use, along with sleep disruption and panic attacks. To help minimize the risks, it’s a good idea to start with low, precisely measured doses, and have an experienced sitter present. 5-METHOXY-DMT

  Alternatively, you may wish to be in the presence of a more actively engaged facilitator, or ‘practitioner’—a 5-MeO-DMT specialist trained to guide and help integrate your experience. Click here for in-depth tips on how to choose the right person or group for the job and what you should expect them to do. 5-METHOXY-DMT

  What should I do in the event of a 5-MeO-DMT overdose?

  5-MeO-DMT overdose reports indicate a risk of breathing difficulties and loss of consciousness. If this happens, roll the person onto their side and call the emergency services, keeping them calm until paramedics arrive. A responsible, trained sitter may also need to provide mouth-to-mouth resuscitation after checking the airway is clear. 5-METHOXY-DMT

  Is it legal to cultivate natural 5-MeO-DMT sources (5-MeO-DMT plants, 5-MeO-DMT toad species, etc.)?

  Cultivating plant sources of Schedule I drugs is a bit of a legal grey area (except in specified cases like cannabis and peyote, and where entheogenic/psychedelic plants are specifically decriminalized). While the law prohibits “any material containing any quantity” of illegal substances, the likelihood of prosecution is slim. On the other hand, 5-MeO-DMT extraction from any source is definitely illegal and will lead to prosecution if caught. 5-METHOXY-DMT

  Regarding toads, the rules are clearer. In New Mexico, only state residents may collect them without a license. Both residents and non-residents of Arizona need a fishing license to collect a maximum of 10 Colorado River Toads. In California, meanwhile, it’s a misdemeanor to collect toads and possession is against the law. Regardless of the legality, though, the Colorado River Toad is a threatened species. Keeping toads in captivity—not to mention regular “milking”—is found to damage their health. 5-METHOXY-DMT

  5-MeO-DMT is tricky to acquire due to overharvesting, the strain on the Sonoran Desert toad, and legal concerns. To source various psychedelic medicines worldwide, consider Third Wave’s Ultimate Guide to Sourcing Psychedelic Medicines.

  WHAT’S THE SAFEST WAY TO TAKE 5-MeO-DMT ?

  There is no entirely safe way, but vaporizing or smoking 5-MeO-DMT powder is by far the most tried and tested. The onset of effects is shorter than with insufflated or sublingual use. However, some people experience chest pains from the smoke. Others experience no effects whatsoever and prefer intravenous or intramuscular injections. These induce rapid, intense effects even at low doses. Swallowing the drug isn’t recommended due to safety concerns and it’s often ineffective anyway. 5-METHOXY-DMT

  CAN I MICRODOSE WITH5-MeO-DMT?

  As people’s reactions vary immensely, it’s hard to give a reliable microdose range. Some have felt profound effects on less than a threshold dose, while others experience only mild effects from a moderate dose. 5-METHOXY-DMT

  CAN I DEVELOP A TOLERANCE?

  Yes, tolerance develops almost immediately and takes two hours to return to baseline. There is no cross-tolerance with other psychedelics. 5-METHOXY-DMT

  CAN I MIX 5-MeO-DMT WITH OTHER DRUGS?

  It shouldn’t be mixed with MAOIs or RIMAs, including some antidepressants, due to the risk of serotonin syndrome and death. Releasing agents and reuptake inhibitors, for serotonin and dopamine especially, can be dangerous in combination. For this reason, mixing 5-MeO with other psychoactive drugs is discouraged. Combining with alcohol is strongly discouraged due to the risk of vomiting and subsequent choking. 5-METHOXY-DMT

  Is 5-MeO-DMT similar to 5-MeO-MiPT, 5-MeO-DALT, 5-MeO-DiPT, etc.?

  Not necessarily. Substances in the  group may share some basic similarities, but effects and safety can vary. Dosage in particular tends to vary significantly, as does legal status—so it’s unwise to assume they’re interchangeable. 5-METHOXY-DMT

  Here’s a brief overview:

  5-MEO-MIPT

  5-MeO-MiPT, or Moxy, can be taken orally (e.g. as 5-MeO-MiPT HCl) or smoked (as freebase). Threshold effects may be felt from as little as 1-2 mg taken orally (or 10-15 mg 5-MeO-MiPT if smoked). 15+ mg is considered strong or heavy^[56] and the experience can last 5-8 hours.^[57] Some people use 5-MeO-MiPT for sex.^[58] Although it’s possible to buy 5-MeO-MiPT online in the USA, its legal status is unclear. 5-METHOXY-DMT

  5-MEO-DIPT

  5-MeO-DiPT, also known as Foxy or Foxy methoxy, is entactogenic and sexual, similar to 5-MeO-MiPT. It’s usually taken orally as 5-MeO-DiPT HCl (3-15+ mg) and has a duration of up to 8 hours.^[59][60] Although a Schedule I substance in the USA, in Canada, 5-MeO-DiPT is legal.^{[60][61] 5-METHOXY-DMT}

  5-MEO-DALT

  5-MeO-DALT is taken orally as 5-MeO-DALT HCl at a dosage of 4-30+ mg.^[62][63] Like the 5-MeOs described above, it’s mildly psychedelic and often used for sex.^[63][64] Apparently, it also helps alleviate cluster headaches.^[65] You might find 5-MeO-DALT for sale in the USA, given that it’s unscheduled—outside of Florida, at least. But it may be considered an analogue of 5-MeO-DiPT.^{[63][66] 5-METHOXY-DMT}

  5-MEO-AMT

  5-MeO-aMT, or Alpha, has a reported threshold dose of just 0.5 mg, and 6-15 mg may be heavy. Effects are said to last 8-12 hours.^[67] On Erowid, 5-MeO-aMT is linked to a number of hospitalizations and possible deaths following overdose (ranging from 5-50 mg).^[68] It’s reportedly unscheduled in the USA—with the exception of Florida.^[69][66]

  OTHER 5-MEOS

  • 5-MeO-pyr-T: potentially dangerous at just 0.5-3 mg*^[70]
  • 5-MeO-MALT: reportedly euphoric at 15-50 mg oral*^[71]
  • 5-MeO-DET: uncomfortable drunk feeling at 1-3 mg oral*^[72][73]
  • 5-MeO-TMT: sexually stimulating at 65-90 mg; nauseating at 120+ mg
  • 5-MeO-BFE (aka dimemebfe)
  • 5-MeO-DiBF
  • 5-MeO-NiPT
  • 5-MeO-DPT
  • 5-MeO-NMT
  • 5-MeO-MET

  * dose/effects based on limited reports and by no means definitive; included only to give a sense of the variation within the 5-MeO group of substances.